Benedikt Saller

currently	PhD student in the lab of Prof. Olaf Groß, Institute of Neuropathology, Metabolism and Inflammation Research Group, Medical Center - University of Freiburg
2015 – 2017	M. Sc. in Molecular Biotechnology, Technical University of Munich, Germany
2011 – 2015	B. Sc. in Molecular Biotehcnology, Technical University of Munich, Germany

Publications

Schneider KS, Groß CJ, Dreier RF, Saller BS, …, Groß O (2017): The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity. In Cell Reports 21, pp. 3846–3859. DOI: 10.1016/j.celrep.2017.12.018.

Rieblinger B, Fischer K, Kind A, Saller BS, …, Schnieke A (2018): Strong xenoprotective function by single-copy transgenes placed sequentially at a permissive locus. In Xenotransplantation, 2018;25:e12382. DOI: 10.1111/xen.12382.

Publications based on CRC1160 funding

Neuwirt E, Magnani G, Ćiković T, Wöhrle S, Fischer L, Kostina A, Flemming S, Fischenich NJ, Saller BS, Gorka O, Renner S, Agarinis C, Parker CN, Boettcher A, Farady CJ, Kesselring R, Berlin C, Backofen R, Rodriguez-Franco M, Kreutz C, Prinz M, Tholen M, Reinheckel T, Ott T, Groß CJ, Jost PJ, Groß O. 2023. Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis. Sci Signal. 16(768):eabh1083. doi: 10.1126/scisignal.abh1083.

Hamarsheh, S., L. Osswald, B. S. Saller, S. Unger, D. De Feo, J. M. Vinnakota, M. Konantz, F. M. Uhl, H. Becker, M. Lubbert, K. Shoumariyeh, C. Schurch, G. Andrieux, N. Venhoff, A. Schmitt-Graeff, S. Duquesne, D. Pfeifer, M. A. Cooper, C. Lengerke, M. Boerries, J. Duyster, C. M. Niemeyer, M. Erlacher, B. R. Blazar, B. Becher, O. Gross, T. Brummer, and R. Zeiser. 2020. Oncogenic Kras(G12D) causes myeloproliferation via NLRP3 inflammasome activation. Nat Commun 11: 1659.