Marco Prinz

Principal Investigator

Center for Pathology
Institute for Neuropathology
Medical Center – University of Freiburg

Breisacher Straße 64
79106 Freiburg i. Brsg.

Current position

W3 Professor, Director of the Institute for Neuropathology, Center for Pathology,
Medical Center – University of Freiburg

Academic training

1996 Study of Medicine in Berlin

Scientific qualifications

2004 Habilitation in Neuropathology, Georg-August-University Göttingen (Mentor: Prof. W. Brück)
1997 Dissertation in Medicine, Humboldt-University, Medical Hospital (Charité) Berlin (Supervisor: Prof. E.Schulz)

Postgraduate Positions

since 2008 W3 Professor, Director, Institute for Neuropathology,
Medical Center - University of Freiburg
2002 – 2008 Group leader at the Institute of Neuropathology,
Georg-August-University, Göttingen
2001 – 2002 Research Fellow at the Institute of Neuropathology,
University of Zurich, Switzerland
1999 – 2000 Postdoctorate at the Institute of Neuropathology,
University of Zurich, Switzerland
1997 – 1998 Postdoctorate in Cellular Neurosciences at the Max Delbrück Center (MDC), Berlin

Miscellaneous (Honors, Awards)

2020 Gottfried Wilhelm Leibniz Prize
2014 Sobek Prize (Sobek Foundation)
2014 Writer Prize (Cluster of Excellence BIOSS)
2007 Hans Georg Queckenstedt Prize (DMSG)
2006 Young Investigator Award
(International Cytokine Society, Vienna, Austria)
2005 Pfizer Research Prize for Medicine (University of Freiburg)
2004 H.G. Creutzfeldt Prize (University of Kiel)

link to all publications from M. Prinz: Pubmed

Publications based on CRC1160 funding

Berghoff SA, Spieth L, Sun T, Hosang L, Schlaphoff L, Depp C, Düking T, Winchenbach J, Neuber J, Ewers D, Scholz P, van der Meer F, Cantuti-Castelvetri L, Sasmita AO, Meschkat M, Ruhwedel T, Möbius W, Sankowski R, Prinz M, Huitinga I, Sereda MW, Odoardi F, Ischebeck T, Simons M, Stadelmann-Nessler C, Edgar JM, Nave KA, Saher G. 2020. Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nat Neurosci. 24(1):47-60. doi: 10.1038/s41593-020-00757-6.

Borst, K., and M. Prinz. 2020. Deciphering the heterogeneity of myeloid cells during neuroinflammation in the single cell era. Brain Pathol. doi: 10.1111/bpa.12910. Online ahead of print.

Bassett DS, Cullen KE, Eickhoff SB, Farah MJ, Goda Y, Haggard P, Hu H, Hurd YL, Josselyn SA, Khakh BS, Knoblich JA, Poirazi P, Poldrack RA, Prinz M, Roelfsema PR, Spires-Jones TL, Sur M, Ueda HR. 2020. Reflections on the past two decades of neuroscience. Nat Rev Neurosci. doi: 10.1038/s41583-020-0363-6. Online ahead of print.

Mezö C, Dokalis N, Mossad O, Staszewski O, Neuber J, Yilmaz B, Schnepf D, de Agüero MG, Ganal-Vonarburg SC, Macpherson AJ, Meyer-Luehmann M, Staeheli P, Blank T, Prinz M, Erny D. 2020. Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease. Acta Neuropathol Commun. 8(1):119. doi: 10.1186/s40478-020-00988-5.

Masuda, T., L. Amann, R. Sankowski, O. Staszewski, M. Lenz, P. d Errico, N. Snaidero, M. J. Costa Jordao, C. Bottcher, K. Kierdorf, S. Jung, J. Priller, T. Misgeld, A. Vlachos, M. M. Luehmann, K. P. Knobeloch, and M. Prinz. 2020. Novel Hexb-based tools for studying microglia in the CNS. Nat Immunol 21: 802-815.

Amann, L., and M. Prinz. 2020. The origin, fate and function of macrophages in the peripheral nervous system – an update. Int Immunolpii. doi: 10.1093/intimm/dxaa030. [Epub ahead of print].

Ydens, E., L. Amann, B. Asselbergh, C. L. Scott, L. Martens, D. Sichien, O. Mossad, T. Blank, S. De Prijck, D. Low, T. Masuda, Y. Saeys, V. Timmerman, R. Stumm, F. Ginhoux, M.  Prinz, S. Janssens, and M. Guilliams. 2020. Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury. Nat Neurosci 23: 676-689.

Erny, D., and M. Prinz. 2020. How microbiota shape microglial phenotypes and epigenetics. Glia. doi: 10.1002/glia.23822. [Epub ahead of print]

Masuda, T., R. Sankowski, O. Staszewski, and M. Prinz. 2020. Microglia Heterogeneity in the Single-Cell Era. Cell Rep 30: 1271-1281.

R Mathew N, Vinnakota JM, Apostolova P, Erny D, Hamarsheh S, Andrieux G, Kim JS, Hanke K, Goldmann T, Chappell-Maor L, El-Khawanky N, Ihorst G, Schmidt D, Duyster J, Finke J, Blank T, Boerries M, Blazar BR, Jung S, Prinz M, Zeiser R. 2019. Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia. J Clin Invest. pii: 130272.

Geirsdottir L, David E, Keren-Shaul H, Weiner A, Bohlen SC, Neuber J, Balic A, Giladi A, Sheban F, Dutertre CA, Pfeifle C, Peri F, Raffo-Romero A, Vizioli J, Matiasek K, Scheiwe C, Meckel S, Mätz-Rensing K, van der Meer F, Thormodsson FR, Stadelmann C, Zilkha N, Kimchi T, Ginhoux F, Ulitsky I, Erny D, Amit I, Prinz M. 2019.  Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program. Cell. 179:1609-1622.

Sankowski R, Böttcher C, Masuda T, Geirsdottir L, Sagar, Sindram E, Seredenina T, Muhs A, Scheiwe C, Shah MJ, Heiland DH, Schnell O, Grün D, Priller J, Prinz M. 2019. Mapping microglia states in the human brain through the integration of high-dimensional techniques. Nat Neurosci. 22(12):2098-2110. doi: 10.1038/s41593-019-0532-y. Epub 2019 Nov 18.

Nikolaos Dokalis & Marco Prinz. 2019. Resolution of neuroinflammation: mechanisms and potential therapeutic option. Semin Immunopathol. 41(6):699-709. doi: 10.1007/s00281-019-00764-1. Epub 2019 Nov 8.

Kierdorf K, Masuda T, Jordão MJC, Prinz M. 2019. Macrophages at CNS interfaces: ontogeny and function in health and disease. Nat Rev Neurosci. 20(9):547-562. Review.

Fischer, J., C. Walter, A. Tonges, H. Aleth, M. J. C. Jordao, M. Leddin, V. Groning, T. Erdmann, G. Lenz, J. Roth, T. Vogl, M. Prinz, M. Dugas, I. D. Jacobsen, and F. Rosenbauer. 2019. Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils. Nat Immunol. 20(5):546-558.

Masuda, T., R. Sankowski, O. Staszewski, C. Bottcher, L. Amann, Sagar, C. Scheiwe, S. Nessler, P. Kunz, G. van Loo, V. A. Coenen, P. C. Reinacher, A. Michel, U. Sure, R. Gold, D. Grun, J. Priller, C. Stadelmann, and M. Prinz. 2019. Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution. Nature 566: 388-392.

Jordao, M. J. C., R. Sankowski, S. M. Brendecke, Sagar, G. Locatelli, Y. H. Tai, T. L. Tay, E. Schramm, S. Armbruster, N. Hagemeyer, O. Gross, D. Mai, O. Cicek, T. Falk, M. Kerschensteiner, D. Grun, and M. Prinz. 2019. Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation. Science. 363(6425). pii:eaat7554.

Shemer, A., J. Grozovski, T. L. Tay, J. Tao, A. Volaski, P. Suss, A. Ardura-Fabregat, M. Gross-Vered, J. S. Kim, E. David, L. Chappell-Maor, L. Thielecke, C. K. Glass, K. Cornils, Prinz, and S. Jung. 2018. Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge. Nat Commun 9: 5206.

Tay, T. L., Sagar, J. Dautzenberg, D. Grun, and Prinz. 2018. Unique microglia recovery population revealed by single-cell RNAseq following neurodegeneration. Acta Neuropathol Commun 6: 87.

Locatelli, G., D. Theodorou, A. Kendirli, M. J. C. Jordao, O. Staszewski, K. Phulphagar, L. Cantuti-Castelvetri, A. Dagkalis, A. Bessis, M. Simons, F. Meissner, Prinz, and M. Kerschensteiner. 2018. Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model. Nat Neurosci 21: 1196-1208.

Voet, S., C. Mc Guire, N. Hagemeyer, A. Martens, A. Schroeder, P. Wieghofer, C. Daems, O. Staszewski, L. V. Walle, M. J. C. Jordao, M. Sze, H. K. Vikkula, D. Demeestere, G. Van Imschoot, C. L. Scott, E. Hoste, A. Goncalves, M. Guilliams, S. Lippens, C. Libert, R. E. Vandenbroucke, K. W. Kim, S. Jung, Z. Callaerts-Vegh, P. Callaerts, J. de Wit, M. Lamkanfi, Prinz, and G. van Loo. 2018. A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation. Nat Commun 9: 2036.

Rothhammer, V., D. M. Borucki, E. C. Tjon, M. C. Takenaka, C. C. Chao, A. Ardura-Fabregat, K. A. de Lima, C. Gutierrez-Vazquez, P. Hewson, O. Staszewski, M. Blain, L. Healy, T. Neziraj, M. Borio, M. Wheeler, L. L. Dragin, D. A. Laplaud, J. Antel, J. I. Alvarez, Prinz, and F. J. Quintana. 2018. Microglial control of astrocytes in response to microbial metabolites. Nature 557: 724-728.

Mathew NR, Baumgartner F, Braun L, O’Sullivan D, Thomas S, Waterhouse M, Müller TA, Hanke K, Taromi S, Apostolova P, Illert AL, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lübbert M, Rummelt C, Bertz H, Wäsch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rösler W, Doostkam S, Meckel S,Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stölzel F, Ordemann R, Müller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kröger N, Ayuk F, Vago L, Ciceri F, Müller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dörfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Börries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K, Shah O, Negrin RS, Nagler A, Prinz M, Burchert A, Neubauer A, Beelen D, Mackensen A, von Bubnoff N, Herr W, Becher B, Socié G, Caligiuri MA, Ruggiero E, Bonini C, Häcker G, Duyster J, Finke J, Pearce E, Blazar BR, Zeiser R. Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nat Med. 24: 282-291.

Datta, M., O. Staszewski, E. Raschi, M. Frosch, N. Hagemeyer, T. L. Tay, T. Blank, M. Kreutzfeldt, D. Merkler, S. Ziegler-Waldkirch, P. Matthias, M. Meyer-Luehmann, and Prinz. 2018. Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner. Immunity 48: 514-529 e516.

Deczkowska, A., O. Matcovitch-Natan, A. Tsitsou-Kampeli, S. Ben-Hamo, R. Dvir-Szternfeld, A. Spinrad, O. Singer, E. David, D. R. Winter, L. K. Smith, A. Kertser, K. Baruch, N. Rosenzweig, A. Terem, Prinz, S. Villeda, A. Citri, I. Amit, and M. Schwartz. 2017. Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner. Nat Commun 8: 717.

Quintana, F. J., and M. Prinz. 2017. A gut feeling about multiple sclerosis. Proc Natl Acad Sci U S A 114: 10528-10529

Mass, E., C. E. Jacome-Galarza, T. Blank, T. Lazarov, B. H. Durham, N. Ozkaya, A. Pastore, M. Schwabenland, Y. R. Chung, M. K. Rosenblum, Prinz, O. Abdel-Wahab, and F. Geissmann. 2017. A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease. Nature 549: 389-393.

Tay, T. L., D. Mai, J. Dautzenberg, F. Fernandez-Klett, G. Lin, Sagar, M. Datta, A. Drougard, T. Stempfl, A. Ardura-Fabregat, O. Staszewski, A. Margineanu, A. Sporbert, L. M. Steinmetz, J. A. Pospisilik, S. Jung, J. Priller, D. Grun, O. Ronneberger, and Prinz. 2017. A new fate mapping system reveals context-dependent random or clonal expansion of microglia. Nat Neurosci 20: 793-803.

Prinz, M., D. Erny, and N. Hagemeyer. 2017. Ontogeny and homeostasis of CNS myeloid cells. Nat Immunol 18: 385-392.

Prinz M, Priller J. 2017. The role of peripheral immune cells in the CNS in steady state and disease. Nat Neurosci. 20(2):136-144. Review.

Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar, Erny D, Stefanowski J, Rogell L, Klein C, Gharun K, Follo M, Seidl M, Kremer B, Münke N, Senges J, Fliegauf M, Aschman T, Pfeifer D, Sarrazin S, Sieweke MH, Wagner D, Dierks C, Haaf T, Ness T, Zaiss MM, Voll RE, Deshmukh SD, Prinz M, Goldmann T, Hölscher C, Hauser AE, Lopez-Contreras AJ, Grün D, Gorgoulis V, Diefenbach A, Henneke P, Triantafyllopoulou A. 2016. DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas. Cell. 167(5):1264-1280.

Peschke K, Achleitner M, Frenzel K, Gerbaulet A, Ada SR, Zeller N, Lienenklaus S, Lesche M, Poulet C, Naumann R, Dahl A, Ravens U, Günther C, Müller W, Knobeloch KP, Prinz M, Roers A, Behrendt R. 2016. Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity. J Immunol. 197:2157-2166.

Erny D, Hrabě de Angelis AL, Prinz M. 2017. Communicating systems in the body: how microbiota and microglia cooperate. Immunology. 150(1):7-15.

Hagemeyer N, Kierdorf K, Frenzel K, Xue J, Ringelhan M, Abdullah Z, Godin I, Wieghofer P, Costa Jordão MJ, Ulas T, Yorgancioglu G, Rosenbauer F, Knolle PA, Heikenwalder M, Schultze JL, Prinz M. 2016. Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation. EMBO J. 35:1730-1744.

Goldmann T, Wieghofer P, Jordão MJ, Prutek F, Hagemeyer N, Frenzel K, Amann L, Staszewski O, Kierdorf K, Krueger M, Locatelli G, Hochgerner H, Zeiser R, Epelman S, Geissmann F, Priller J, Rossi FM, Bechmann I, Kerschensteiner M, Linnarsson S, Jung S, Prinz M. 2016. Origin, fate and dynamics of macrophages at central nervous system interfaces. Nat Immunol. 17(7):797-805.

Brendecke SM, Prinz M. 2015. Do not judge a cell by its cover–diversity of CNS resident, adjoining and infiltrating myeloid cells in inflammation. Semin Immunopathol. 37(6):591-605.