The goal of the CRC 1160
The Collaborative Research Center (CRC) 1160. “Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)” is a research consortium of clinical and basic immunologists exploring the basis of diseases mediated by the immune system.
The CRC sets out to challenge the traditional idea that an “overreaction” or “deviation“ of normal immune responses is pivotal to immune mediated pathology and that, consequently, immunosuppression is the appropriate therapeutic strategy for such disorders. Instead, the conceptual basis of the CRC is the idea that impaired immune reactions constitute a major prerequisite for immunopathology. This is what we call the “IMPATH paradox”. This paradox implies that immune reconstitution and/or immune stimulation rather than immunosuppression represent appropriate therapeutic principles for these forms of immunopathology.
News
Publications
Sindram E, Deau MC, Ligeon LA, Sanchez-Martin P, Nestel S, Jung S, Ruf S, Mishra P, Proietti M, Günther S, Thedieck K, Roussa E, Rambold A, Münz C, Kraft C, Grimbacher B, Gámez-Díaz L. 2025. LRBA deficiency impairs autophagy and contributes to enhanced antigen presentation and T-cell dysregulation. EMBO Rep. 2025 Jun 23. doi: 10.1038/s44319-025-00504-7.
Braun LM, Zeiser R. 2025. Protocol to study in vivo organ-specific migration of apoptotic splenocytes in mice with tumor and immune checkpoint inhibitor-induced colitis. STAR Protoc. 2025 Jun 20;6(2):103878. doi: 10.1016/j.xpro.2025.103878.
Braun LM, Zeiser R. 2025. Protocol to study phagocytosis of apoptotic murine splenocytes by syngeneic antigen-presenting cells in vitro. STAR Protoc. 2025 Jun 14;6(3):103903. doi: 10.1016/j.xpro.2025.103903.
Runge S, von Zedtwitz S, Maucher AM, Bruno P, Osbelt L, Zhao B, Gernand AM, Lesker TR, Gräwe K, Rogg M, Schell C, Boerries M, Strowig T, Andrieux G, Hild B, Rosshart SP. 2025. Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype. Nat Commun. 2025 Jun 12;16(1):5301. doi: 10.1038/s41467-025-60554-2.
Sagar, Ehl S. 2025. γδ T Cells and Inborn Errors of Immunity. Eur J Immunol. 2025 Jun;55(6):e51457. doi: 10.1002/eji.202451457.
Contact
Scientific Manager/Administration
Dr. Heike Ufheil
Institute for Immunodeficiency (IFI),
Center for Chronic Immunodeficiency (CCI)
Medical Center – University of Freiburg
