Immune-mediated pathology as a consequence of impaired immune reactions Research Program
Immune-mediated pathology as a consequence of impaired immune reactions
Immune-mediated pathology as a consequence of impaired immune reactions
Immune-mediated pathology as a consequence of impaired immune reactions

The goal of the CRC 1160

The Collaborative Research Center (CRC) 1160. “Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)” is a research consortium of clinical and basic immunologists exploring the basis of diseases mediated by the immune system.

The CRC sets out to challenge the traditional idea that an “overreaction” or “deviation“ of normal immune responses is pivotal to immune mediated pathology and that, consequently, immunosuppression is the appropriate therapeutic strategy for such disorders. Instead, the conceptual basis of the CRC is the idea that impaired immune reactions constitute a major prerequisite for immunopathology. This is what we call the “IMPATH paradox”. This paradox implies that immune reconstitution and/or immune stimulation rather than immunosuppression represent appropriate therapeutic principles for these forms of immunopathology.

Research Program
More Seminars More Workshops

Publications

Hennig C, Graaf A, Petric PP, Graf L, Schwemmle M, Beer M, Harder T. Porcine Health Manag. 2022. Are pigs overestimated as a source of zoonotic influenza viruses? First published: 2022 Jun 30;8(1):30. doi: 10.1186/s40813-022-00274-x. PMID: 35773676 Free PMC article

Globig AM, Hipp AV, Otto-Mora P, Heeg M, Mayer LS, Ehl S, Schwacha H, Bewtra M, Tomov V, Thimme R, Hasselblatt P, Bengsch B. Nat Commun. 2022. High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature. First published: 2022 Jun 27;13(1):3688. doi: 10.1038/s41467-022-31229-z. PMID: 35760777 Free PMC article.

Globig AM, Mayer LS, Heeg M, Andrieux G, Ku M, Otto-Mora P, Hipp A, Zoldan K, Pattekar A, Rana N, Schell C, Boerries M, Hofmann M, Neumann-Haefelin C, Kuellmer A, Schmidt A, Boettler T, Tomov V, Thimme R, Hasselblatt P, Bengsch B. Gastroenterology. 2022. Exhaustion of CD39-expressing CD8+ T cells in Crohn’s disease is linked to clinical outcome. First published: 2022 Jun 20:S0016-5085(22)00663-1. doi: 10.1053/j.gastro.2022.06.045. Online ahead of print.

Czech M, Zeiser R, Toubai T. Front Immunol. 2022. Editorial on Translational Research in Graft-Versus-Host Disease (GVHD) and Graft-Versus-Tumor (GVT) Effect After Allogeneic Hematopoietic Cell Transplantation. First published: 2022 Jun 8;13:948720. doi: 10.3389/fimmu.2022.948720. eCollection 2022. PMID: 35757690 Free PMC article.

Friedrich M, Hahn M, Michel J, Sankowski R, Kilian M, Kehl N, Günter M, Bunse T, Pusch S, von Deimling A, Wick W, Autenrieth SE, Prinz M, Platten M, Bunse L. Neuro Oncol. 2022. Dysfunctional dendritic cells limit antigen-specific T cell response in glioma. First Published: 2022 May 24:noac138. doi: 10.1093/neuonc/noac138.

More Publications