Immune-mediated pathology as a consequence of impaired immune reactions Research Program
Immune-mediated pathology as a consequence of impaired immune reactions
Immune-mediated pathology as a consequence of impaired immune reactions
Immune-mediated pathology as a consequence of impaired immune reactions

The goal of the CRC 1160

The Collaborative Research Center (CRC) 1160. “Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)” is a research consortium of clinical and basic immunologists exploring the basis of diseases mediated by the immune system.

The CRC sets out to challenge the traditional idea that an “overreaction” or “deviation“ of normal immune responses is pivotal to immune mediated pathology and that, consequently, immunosuppression is the appropriate therapeutic strategy for such disorders. Instead, the conceptual basis of the CRC is the idea that impaired immune reactions constitute a major prerequisite for immunopathology. This is what we call the “IMPATH paradox”. This paradox implies that immune reconstitution and/or immune stimulation rather than immunosuppression represent appropriate therapeutic principles for these forms of immunopathology.

Research Program

Seminars

Jul 06, 2020 04:15 PM

Metabolism Club/CIBSS Seminar (Venue: Otto-Krayer House, Albertstr. 25)

Title: tba

Jul 06, 2020 04:15 PM

Inflammation conference on ‘Lessons from a rare genetic disease’ (Venue: ZTZ, Breisacher Str. 115)

Title: Too much or too little cytokines in severe Covid19? Lessons from a rare genetic disease help to better understand a viral infection

Sep 07, 2020 04:15 PM

Metabolism Club/CIBSS Seminar (Venue: Otto-Krayer House, Albertstr. 25)

Title: tba

Oct 05, 2020 04:15 PM

Metabolism Club/CIBSS Seminar (Venue: Otto-Krayer House, Albertstr. 25)

Title: tba

More Seminars

Publications

Gather, R., P. Aichele, N. Goos, J. Rohr, H. Pircher, T. Kogl, R. Zeiser, H. Hengel, A. Schmitt-Graff, C. Weaver, and S. Ehl. 2020. Trigger-dependent differences determine therapeutic outcome in murine primary hemophagocytic lymphohistiocytosis. Eur J Immunol. doi: 10.1002/eji.201948123. [Epub ahead of print].

Wegehaupt, O., K. Wustrau, K. Lehmberg, and S. Ehl. 2020. Cell Versus Cytokine – Directed Therapies for Hemophagocytic Lymphohistiocytosis (HLH) in Inborn Errors of Immunity. Front Immunol 11: 808.

Amann, L., and M. Prinz. 2020. The origin, fate and function of macrophages in the peripheral nervous system – an update. Int Immunolpii. doi: 10.1093/intimm/dxaa030. [Epub ahead of print].

Wegehaupt, O., M. Gross, C. Wehr, R. Marks, A. Schmitt-Graeff, M. Uhl, M. Lorenz, K. Schwarz, C. Kratz, C. Niemeyer, and S. Ehl. 2020. TIM-3 deficiency presenting with two clonally unrelated episodes of mesenteric and subcutaneous panniculitis-like T-cell lymphoma and hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 67: e28302.

Kalina, T., R. S. Abraham, Rizzi, and M. van der Burg. 2020. Editorial: Application of Cytometry in Primary Immunodeficiencies. Front Immunol 11: 463.

Hamarsheh, S., L. Osswald, B. S. Saller, S. Unger, D. De Feo, J. M. Vinnakota, M. Konantz, F. M. Uhl, H. Becker, M. Lubbert, K. Shoumariyeh, C. Schurch, G. Andrieux, N. Venhoff, A. Schmitt-Graeff, S. Duquesne, D. Pfeifer, M. A. Cooper, C. Lengerke, M. Boerries, J. Duyster, C. M. Niemeyer, M. Erlacher, B. R. Blazar, B. Becher, O. Gross, T. Brummer, and R. Zeiser. 2020. Oncogenic Kras(G12D) causes myeloproliferation via NLRP3 inflammasome activation. Nat Commun 11: 1659.

van Teijlingen Bakker, N., and E. J. Pearce. 2020. Cell-intrinsic metabolic regulation of mononuclear phagocyte activation: Findings from the tip of the iceberg. Immunol Rev 295: 54-67

Beziat, V., S. J. Tavernier, Y. H. Chen, C. S. Ma, M. Materna, A. Laurence, J. Staal, D. Aschenbrenner, L. Roels, L. Worley, K. Claes, L. Gartner, L. A. Kohn, M. De Bruyne, K. Schmitz-Abe, L. M. Charbonnier, S. Keles, J. Nammour, N. Vladikine, M. R. L. Maglorius Renkilaraj, Y. Seeleuthner, M. Migaud, J. Rosain, M. Jeljeli, B. Boisson, E. Van Braeckel, J. A. Rosenfeld, H. Dai, L. C. Burrage, D. R. Murdock, B. N. Lambrecht, V. Avettand-Fenoel, T. P. Vogel, N. Undiagnosed Diseases, C. R. Esther, S. Haskologlu, F. Dogu, P. Ciznar, D. Boutboul, M. Ouachee-Chardin, J. Amourette, M. N. Lebras, C. Gauvain, C. Tcherakian, A. Ikinciogullari, R. Beyaert, L. Abel, J. D. Milner, B. Grimbacher, L. J. Couderc, M. J. Butte, A. F. Freeman, E. Catherinot, C. Fieschi, T. A. Chatila, S. G. Tangye, H. H. Uhlig, F. Haerynck, J. L. Casanova, and A. Puel. 2020. Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome. J Exp Med 217. pii: e20191804. doi: 10.1084/jem.20191804.

Erny, D., and M. Prinz. 2020. How microbiota shape microglial phenotypes and epigenetics. Glia. doi: 10.1002/glia.23822. [Epub ahead of print]

Klocperk, A., S. Unger, D. Friedmann, M.  Seidl, K. Zoldan, J. Pfeiffer, O. Hausmann, V. Benes, G. Andrieux, T. Boettler, A. Sediva, B. Bengsch, and K. Warnatz. 2020. Exhausted phenotype of follicular CD8 T cells in CVID. J Allergy Clin Immunol. pii: S0091-6749(20)30333-X. doi: 10.1016/j.jaci.2020.02.025. [Epub ahead of print]

Troilo, A., C. Wehr, I. Janowska, N. Venhoff, J. Thiel, J. Rawluk, N. Frede, J. Staniek, R. Lorenzetti, M. T. Schleyer, G. W. Herget, L. Konstantinidis, M. Erlacher, M. Proietti, N. Camacho-Ordonez, R. E. Voll, B. Grimbacher, K. Warnatz, U. Salzer, and M. Rizzi. 2020. Nonpermissive bone marrow environment impairs early B-cell development in common variable immunodeficiency. Blood 135: 1452-1457.

Marschner, D., M. Falk, N. R. Javorniczky, K. Hanke-Muller, J. Rawluk, Schmitt-Graeff, F. Simonetta, E. Haring, S. Dicks, M. Ku, S. Duquesne, K. Aumann, D. Rafei-Shamsabadi, F. Meiss, P. Marschner, M. Boerries, R. S. Negrin, J. Duyster, R. Zeiser, and N. Kohler. 2020. MicroRNA-146a regulates immune-related adverse events caused by immune checkpoint inhibitors. JCI insight 5. pii: 132334. doi: 10.1172/jci.insight.132334.

Zenke S, Palm MM, Braun J, Gavrilov A, Meiser P, Böttcher JP, Beyersdorf N, Ehl S, Gerard A, Lämmermann T, Schumacher TN, Beltman JB, Rohr JC. 2020. Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics. Immunity. 52(2):313-327.e7.

Thian, M., B. Hoeger, A. Kamnev, F. Poyer, S. Kostel Bal, M. Caldera, R. Jimenez-Heredia, J. Huemer, W. F. Pickl, M. Gross, S. Ehl, C. L. Lucas, J. Menche, C. Hutter, A. Attarbaschi, L. Dupre, and K. Boztug. 2020. Germline biallelic PIK3CG mutations in a multifaceted immunodeficiency with immune dysregulation. Haematologica. pii: haematol.2019.231399. doi: 10.3324/haematol.2019.231399. [Epub ahead of print]

Ammann, S., S. Fuchs, L. Martin-Martin, C. N. Castro, B. Spielberger, C. Klemann, R. Elling, M. Heeg, C. Speckmann, I. Hainmann, P. Kaiser-Labusch, G. Horneff, J. Thalhammer, R. G. Bredius, U. Z. Stadt, K. Lehmberg, I. Fuchs, C. von Spee-Mayer, P. Henneke, and S. Ehl. 2020. Functional flow cytometry of monocytes for routine diagnosis of innate primary immunodeficiencies. J Allergy Clin Immunol 145: 434-437 e434.

Binder, B., and R. Thimme. 2020. CD4+ T cell responses in human viral infection: lessons from hepatitis C. J Clin Invest. pii: 133222. doi: 10.1172/JCI133222. [Epub ahead of print]

Cekic, S., J. M. Hartberger, S. Frey-Jakobs, H. Huriyet, M. B. Hortoglu, J. C. Neubauer, Y. Karali, C. D. Abakay, O. Saraydaroglu, T. Cavas, B. Grimbacher, and S. S. Kilic. 2020. Cancer Tendency in a Patient with ZNF341 Deficiency. J Clin Immunol. doi: 10.1007/s10875-020-00756-z. [Epub ahead of print]

Masuda, T., R. Sankowski, O. Staszewski, and M. Prinz. 2020. Microglia Heterogeneity in the Single-Cell Era. Cell Rep 30: 1271-1281.

van de Ven A, Mader I, Wolff D, Goldacker S, Fuhrer H, Rauer S, Grimbacher B, Warnatz K. 2019. Structural non-infectious manifestations of the central nervous system in common variable immunodeficiency disorders. J Allergy Clin Immunol Pract. pii: S2213-2198(19)31026-8.

R Mathew N, Vinnakota JM, Apostolova P, Erny D, Hamarsheh S, Andrieux G, Kim JS, Hanke K, Goldmann T, Chappell-Maor L, El-Khawanky N, Ihorst G, Schmidt D, Duyster J, Finke J, Blank T, Boerries M, Blazar BR, Jung S, Prinz M, Zeiser R. 2019. Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia. J Clin Invest. pii: 130272.

Geirsdottir L, David E, Keren-Shaul H, Weiner A, Bohlen SC, Neuber J, Balic A, Giladi A, Sheban F, Dutertre CA, Pfeifle C, Peri F, Raffo-Romero A, Vizioli J, Matiasek K, Scheiwe C, Meckel S, Mätz-Rensing K, van der Meer F, Thormodsson FR, Stadelmann C, Zilkha N, Kimchi T, Ginhoux F, Ulitsky I, Erny D, Amit I, Prinz M. 2019.  Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program. Cell. 179:1609-1622.

Schröder C, Sogkas G, Fliegauf M, Dörk T, Liu D, Hanitsch LG, Steiner S, Scheibenbogen C, Jacobs R, Grimbacher B, Schmidt RE, Atschekzei F. 2019. Late-Onset Antibody Deficiency Due to Monoallelic Alterations in NFKB1. Front Immunol. 10:2618.

Gebhardt, A., V. Bergant, D. Schnepf, M. Moser, A. Meiler, D. Togbe, C. Mackowiak, L. S. Reinert, S. R. Paludan, B. Ryffel, A. Stukalov, P. Staeheli, and A. Pichlmair. 2019. The alternative cap-binding complex is required for antiviral defense in vivo. PLoS Pathog 15: e1008155.

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