Immune-mediated pathology as a consequence of impaired immune reactions Research Program
Immune-mediated pathology as a consequence of impaired immune reactions
Immune-mediated pathology as a consequence of impaired immune reactions
Immune-mediated pathology as a consequence of impaired immune reactions

The goal of the CRC 1160

The Collaborative Research Center (CRC) 1160. “Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)” is a research consortium of clinical and basic immunologists exploring the basis of diseases mediated by the immune system.

The CRC sets out to challenge the traditional idea that an “overreaction” or “deviation“ of normal immune responses is pivotal to immune mediated pathology and that, consequently, immunosuppression is the appropriate therapeutic strategy for such disorders. Instead, the conceptual basis of the CRC is the idea that impaired immune reactions constitute a major prerequisite for immunopathology. This is what we call the “IMPATH paradox”. This paradox implies that immune reconstitution and/or immune stimulation rather than immunosuppression represent appropriate therapeutic principles for these forms of immunopathology.

Research Program
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Publications

Susana Minguet, Alexander Nyström, Dimitra Kiritsi, Marta Rizzi. 2022. Inborn errors of immunity and immunodeficiencies: Antibody-mediated pathology and autoimmunity as a consequence of impaired immune reactions. Eur J Immunol, First published: 20 April 2022; doi.org/10.1002/eji.202149529

Schauer F, Nyström A, Kunz M, Hübner S, Scholl S, Athanasiou I, Alter S, Fischer J, Has C, Kiritsi D. 2022. Case Report: Diagnostic and Therapeutic Challenges in Severe Mechanobullous Epidermolysis Bullosa Acquisita. Front Immunol. 13:883967.  doi: 10.3389/fimmu.2022.883967.

Haimovici A, Höfer C, Badr MT, Bavafaye Haghighi E, Amer T, Boerries M, Bronsert P, Glavynskyi I, Fanfone D, Ichim G, Thilmany N, Weber A, Brummer T, Spohr C, Öllinger R, Janssen KP, Rad R, Häcker G. 2022. Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse. Cell Death Dis. 2022 13(4):315. doi: 10.1038/s41419-022-04768-y.

Zeiser R, Warnatz K, Rosshart S, Sagar, Tanriver Y. 2022. GVHD, IBD and primary immunodeficiencies: The gut as a target of immunopathology resulting from impaired immunity. Eur J Immunol.  doi: 10.1002/eji.202149530.

Mossad, O., B. Batut, B. Yilmaz, N. Dokalis, C. Mezo, E. Nent, L. S. Nabavi, M. Mayer, F. J. M. Maron, J. M. Buescher, M. G. de Aguero, A. Szalay, T. Lammermann, A. J. Macpherson, S. C. Ganal-Vonarburg, R. Backofen, D. Erny, M. Prinz, and T. Blank. 2022. Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N(6)-carboxymethyllysine. Nat Neurosci 25: 295-305

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