The goal of the CRC 1160
The Collaborative Research Center (CRC) 1160. “Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)” is a research consortium of clinical and basic immunologists exploring the basis of diseases mediated by the immune system.
The CRC sets out to challenge the traditional idea that an “overreaction” or “deviation“ of normal immune responses is pivotal to immune mediated pathology and that, consequently, immunosuppression is the appropriate therapeutic strategy for such disorders. Instead, the conceptual basis of the CRC is the idea that impaired immune reactions constitute a major prerequisite for immunopathology. This is what we call the “IMPATH paradox”. This paradox implies that immune reconstitution and/or immune stimulation rather than immunosuppression represent appropriate therapeutic principles for these forms of immunopathology.
News
Landesforschungspreis Baden-Württemberg für Angewandte Forschung for Scientist of CRC 1160
Feb 27, 2026 –
Prof. Dr. Robert Zeiser, principal investigator of CRC 1160 (B09, B10), has been awarded the Landesforschungspreis Baden-Württemberg für Angewandte Forschung for his pioneering work in cancer medicine.
Publications
Stokic-Trtica V, Steffen J, Gao X, Düsedau HP, Boulekou S, Arnold SJ, Triantafyllopoulou A, Romagnani C, Diefenbach A, Tanriver Y, Dunay IR, Klose CSN. 2026. Eomes fate-labeling reveals a subset of Eomeslo NK cells that exhibits an ILC1-like phenotype. Mucosal Immunol. 19(4):100342. doi: 10.1016/j.mucimm.2026.04.003.
Groß PR, Petersen S, Wang Z, Shamshiri B, de Maissin H, Lucas S, Gorka O, Heß L, Marco-Rius I, Mangas-Florencio L, Martins AF, Boehm-Sturm P, Zaitsev M, Zeiser R, Hövener JB, Reinheckel T, Groß O, Schmidt AB. 2026. Minute-Scale Repeated Metabolic Probing of Living Cells Enabled by Rapid Parahydrogen-Based Hyperpolarization. Angew Chem Int Ed Engl. 65(34):e4855536. doi: 10.1002/anie.4855536.
Cousin V, Graumann A, Geiger V, Sökler D, Bez P, Gutenberger S, Glaser C, Andrieux G, Boerries M, Frye BC, Zissel G, Calvillo CL, Rodriguez-Ubreva J, Ballestar E, Hauck F, Voll RE, Chevalier N, Keller B, Warnatz K. 2026. Elevated IL-10 is Linked With the Expansion of T-bethighCD21low B Cells in Patients With Common Variable Immunodeficiency. J Clin Immunol. 46(1):83. doi: 10.1007/s10875-026-02058-2.
Obwegs D, Oschwald A, Koetter LM, Crisand C, Doerr S, Bruder K, Runge S, Ghanem N, Fuchs V, Eckert M, Koengeter C, Schaffer AM, Amann L, Papaioannou S, Rollenske T, Kolter J, Erny D, Prinz M, Minguet S, Schamel WW, Henneke P, Rosshart SP, Kierdorf K, Sagar. 2026. Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiota. Sci Adv. 12(33):eaec9180. doi: 10.1126/sciadv.aec9180.
Holzmüller V, Gawron J, Burk AC, Stell AV, Baur AS, Zähringer A, Fetsch V, Mäder A, Hartmann A, Talvard-Balland N, Krishna N, Cunnion K, Thienel U, Martini P, Glenn L, Ferrara JL, Al Malki MM, Choe H, Pérez-Simón JA, Schmitt-Graeff A, Buescher J, Köhler N, Mansoori Moghadam Z, Henneke P, Andrieux G, Boerries M, Zeiser R. 2026. Pegtarazimod limits acute graft-versus-host disease mortality and severity in mice and is tolerated in patients. J Clin Invest. 4:e205864. doi: 10.1172/JCI205864.
Contact
Scientific Manager/Administration
Dr. Heike Ufheil
Institute for Immunodeficiency (IFI),
Center for Chronic Immunodeficiency (CCI)
Medical Center – University of Freiburg
