Immune-mediated pathology as a consequence of impaired immune reactions Research Program
Immune-mediated pathology as a consequence of impaired immune reactions
Immune-mediated pathology as a consequence of impaired immune reactions
Immune-mediated pathology as a consequence of impaired immune reactions

The goal of the CRC 1160

The Collaborative Research Center (CRC) 1160. “Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)” is a research consortium of clinical and basic immunologists exploring the basis of diseases mediated by the immune system.

The CRC sets out to challenge the traditional idea that an “overreaction” or “deviation“ of normal immune responses is pivotal to immune mediated pathology and that, consequently, immunosuppression is the appropriate therapeutic strategy for such disorders. Instead, the conceptual basis of the CRC is the idea that impaired immune reactions constitute a major prerequisite for immunopathology. This is what we call the “IMPATH paradox”. This paradox implies that immune reconstitution and/or immune stimulation rather than immunosuppression represent appropriate therapeutic principles for these forms of immunopathology.

Research Program

Seminars

Oct 05, 2020 04:15 PM

Metabolism Club/CIBSS Seminar (Venue: Otto-Krayer House, Albertstr. 25)

Title: tba

Oct 19, 2020

CCI: Pascal Schneider (Venue: ZTZ, Breisacher Str. 115)

Title: Biochemical characterisation of endogenous human BAFF and APRIL

Nov 02, 2020 04:15 PM

Metabolism Club/CIBSS Seminar (Venue: Otto-Krayer House, Albertstr. 25)

Title: tba

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Publications

Bassett DS, Cullen KE, Eickhoff SB, Farah MJ, Goda Y, Haggard P, Hu H, Hurd YL, Josselyn SA, Khakh BS, Knoblich JA, Poirazi P, Poldrack RA, Prinz M, Roelfsema PR, Spires-Jones TL, Sur M, Ueda HR. 2020. Reflections on the past two decades of neuroscience. Nat Rev Neurosci. doi: 10.1038/s41583-020-0363-6. Online ahead of print.

Nyström A, Kiritsi D. 2020. Transmembrane collagens – unexplored mediators of epidermal-dermal communication and tissue homeostasis. Exp Dermatol. doi: 10.1111/exd.14180. Online ahead of print.

Tran V, Ledwith MP, Thamamongood T, Higgins CA, Tripathi S, Chang MW, Benner C, García-Sastre A, Schwemmle M, Boon ACM, Diamond MS, Mehle A. 2020. Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs. Nat Microbiol. doi: 10.1038/s41564-020-0778-x. Online ahead of print.

Kemming J, Thimme R, Neumann-Haefelin C. 2020. Adaptive Immune Response against Hepatitis C Virus. Int J Mol Sci. 21(16):E5644. doi: 10.3390/ijms21165644.

van Schewick CM, Nöltner C, Abel S, Burns SO, Workman S, Symes A, Guzman D, Proietti M, Bulashevska A, Moreira F, Soetedjo V, Lowe DM, Grimbacher B. 2020. Altered Microbiota, Impaired Quality of Life, Malabsorption, Infection, and Inflammation in CVID Patients With Diarrhoea. Front Immunol. 11:1654. doi: 10.3389/fimmu.2020.01654. eCollection 2020.

Mezö C, Dokalis N, Mossad O, Staszewski O, Neuber J, Yilmaz B, Schnepf D, de Agüero MG, Ganal-Vonarburg SC, Macpherson AJ, Meyer-Luehmann M, Staeheli P, Blank T, Prinz M, Erny D. 2020. Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease. Acta Neuropathol Commun. 8(1):119. doi: 10.1186/s40478-020-00988-5.

Hartl FA, Beck-Garcìa E, Woessner NM, Flachsmann LJ, Cárdenas RMV, Brandl SM, Taromi S, Fiala GJ, Morath A, Mishra P, Yousefi OS, Zimmermann J, Hoefflin N, Köhn M, Wöhrl BM, Zeiser R, Schweimer K, Günther S, Schamel WW, Minguet S. 2020. Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function. Nat Immunol. 21(8):902-913. doi: 10.1038/s41590-020-0732-3. Epub 2020 Jul 20.

Haring E, Uhl FM, Andrieux G, Proietti M, Bulashevska A, Sauer B, Braun LM, de Vega Gomez E, Esser PR, Martin SF, Pfeifer D, Follo M, Schmitt-Graeff A, Buescher J, Duyster J, Grimbacher B, Boerries M, Pearce EL, Zeiser R, Apostolova P. Haematologica. 2020. Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect. Jul 16:haematol.2019.242990. doi: 10.3324/haematol.2019.242990. Online ahead of print.

Hofmann M, Thimme R. 2020. Hepatitis B vaccine and NK cells: a new player in memory. Gut. 15:gutjnl-2020-321151. doi: 10.1136/gutjnl-2020-321151. Online ahead of print.

Hamarsheh S, Zeiser R. 2020. NLRP3 Inflammasome Activation in Cancer: A Double-Edged Sword. Front Immunol. 8;11:1444. doi: 10.3389/fimmu.2020.01444. eCollection 2020.

Blincoe A, Heeg M, Campbell PK, Hines M, Khojah A, Klein-Gitelman M, Talano JA, Speckmann C, Touzot F, Lankester A, Legger GE, Rivière JG, Garcia-Prat M, Alonso L, Putti MC, Lehmberg K, Maier S, El Chazli Y, Elmaksoud MA, Astigarraga I, Kurjane N, Bulina I, Kenina V, Bryceson Y, Rascon J, Lortie A, Goldstein G, Booth C, Worth A, Wassmer E, Schmitt EG, Warren JT, Bednarski JJ, Ali S, Chiang KY, Krueger J, Henry MM, Holland SM, Marsh RA, Ehl S, Haddad E. 2020. Neuroinflammatory Disease as an Isolated Manifestation of Hemophagocytic Lymphohistiocytosis. J Clin Immunol. 40(6):901-916. doi: 10.1007/s10875-020-00814-6. Epub 2020 Jul 7.

Wolf T, Jin W, Zoppi G, Vogel IA, Akhmedov M, Bleck CKE, Beltraminelli T, Rieckmann JC, Ramirez NJ, Benevento M, Notarbartolo S, Bumann D, Meissner F, Grimbacher B, Mann M, Lanzavecchia A, Sallusto F, Kwee I, Geiger R. 2020. Dynamics in protein translation sustaining T cell preparedness. Nat Immunol. 21(8):927-937. doi: 10.1038/s41590-020-0714-5. Epub 2020 Jul 6.

Wustrau K, Greil J, Sykora KW, Albert MH, Burkhardt B, Lang P, Meisel R, Wössmann W, Beier R, Schulz A, Bader P, Chada M, Kühl JS, Schlegel PG, Speckmann C, Gruhn B, Seidel M, Wawer A, Ozga AK, Janka G, Ehl S, Müller I, Lehmberg K. 2020. Risk factors for mixed chimerism in children with hemophagocytic lymphohistiocytosis after reduced toxicity conditioning. Pediatr Blood Cancer. Jul 3:e28523. doi: 10.1002/pbc.28523. Online ahead of print.

Phillips N, Ke E, Nham A, Seidl M, Freeman B, Abadejos JR, Xiao C, Nemazee D, Ku M, Kirak O. 2020. Prediabetes Induced by a Single Autoimmune B Cell Clone. Front Immunol. 2020 11:1073. doi: 10.3389/fimmu.2020.01073. eCollection 2020.

Amann, L., and M. Prinz. 2020. The origin, fate and function of macrophages in the peripheral nervous system – an update. Int Immunolpii. doi: 10.1093/intimm/dxaa030. [Epub ahead of print].

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