The Collaborative Research Center (CRC) 1160. “Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)” is a research consortium of clinical and basic immunologists exploring the basis of diseases mediated by the immune system.
The CRC sets out to challenge the traditional idea that an “overreaction” or “deviation“ of normal immune responses is pivotal to immune mediated pathology and that, consequently, immunosuppression is the appropriate therapeutic strategy for such disorders. Instead, the conceptual basis of the CRC is the idea that impaired immune reactions constitute a major prerequisite for immunopathology. This is what we call the “IMPATH paradox”. This paradox implies that immune reconstitution and/or immune stimulation rather than immunosuppression represent appropriate therapeutic principles for these forms of immunopathology.
On behalf of the boards of the CRC 1160 – IMPATH and the Center for Chronic Immunodeficiency (CCI), we are delighted to invite you to participate to the “From Paradigms to Paradoxes in Immunity and Immunopathology (PPII) International Conference” – to be held in Freiburg from 06-08 October 2022.
With beginning of 2022, Prof. Dr. Robert Thimme (A02) is a new member in the DFG Senate Committee on Collaborative Research Centers and thus a scientific member of the Grants Committee on Collaborative Research Centers.
Prof. Dr. Marco Prinz (C03) was appointed to the National Academy of Sciences in July 2021.
Dr. Sandra Ammann (B04) was awarded this year’s Walter-Hitzig Prize from the “Arbeitsgemeinschaft Pädiatrische Immunologie (API)” .
Prof. Dr. Stephan Ehl, spokesperson and principal investigator in the CRC 1160 (A01, A07), was elected as President of the German/Swiss/Austrian Working group for Pediatric Immunology (API) for a term of 2 years beginning in May 2021.
Dr. Maike Hofmann (A02) was awarded this year’s Adolf Kussmaul Prize from the Southwest German Society for Gastroenterology at the end of June. Hofmann recently showed that virus-specific CD8 + T cells have a molecular scar and are no longer fully functional, even after a successfully treated chronic hepatitis C virus infection. These findings are relevant for the development of new therapies.
Prof. Dr. Robert Zeiser is honored in the “Translational Research” section for his research that improves therapy after stem cell transplants. The award ceremony can be followed via livestream.
Veranstaltungsreihe Online-Fortbildungen zur Zell- und Gentherapie – Prof. Dr. Toni Cathomen (A07): “Neue Wege in der HIV-Gentherapie mittels Genom-Editierung” am 15.06.2021
Català-Moll F, Ferreté-Bonastre AG, Li T, Weichenhan D, Lutsik P, Ciudad L, Álvarez-Prado ÁF, Rodríguez-Ubreva J, Klemann C, Speckmann C, Vilas-Zornoza A, Abolhassani H, Martínez-Gallo M, Dieli-Crimi R, Rivière JG, Martín-Nalda A, Colobran R, Soler-Palacín P, Kracker S, Hammarström L, Prosper F, Durandy A, Grimbacher B, Plass C, Ballestar E. 2021. Activation-induced deaminase is critical for the establishment of DNA methylation patterns prior to the germinal center reaction. Nucleic Acids Res. 49(9):5057-5073.
Groß M, Speckmann C, May A, Gajardo-Carrasco T, Wustrau K, Maier SL, Panning M, Huzly D, Agaimy A, Bryceson YT, Choo S, Chow CW, Dückers G, Fasth A, Fraitag S, Gräwe K, Haxelmans S, Holzinger D, Hudowenz O, Hübschen JM, Khurana C, Kienle K, Klifa R, Korn K, Kutzner H, Lämmermann T, Ledig S, Lipsker D, Meeths M, Naumann-Bartsch N, Rascon J, Schänzer A, Seidl M, Tesi B, Vauloup-Fellous C, Vollmer-Kary B, Warnatz K, Wehr C, Neven B, Vargas P, Sepulveda FE, Lehmberg K, Schmitt-Graeff A, Ehl S. 2021. Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity. J Allergy Clin Immunol. 24:S0091-6749(21)00809-5.
Emmerich F, Zschiedrich S, Reichenbach-Braun C, Süsal C, Minguet S, Pauly MC, Seidl M.2021. Low Pre-Transplant Caveolin-1 Serum Concentrations Are Associated with Acute Cellular Tubulointerstitial Rejection in Kidney Transplantation. Molecules. 26(9):2648.
Fliegauf M, Krüger R, Steiner S, Hanitsch LG, Büchel S, Wahn V, von Bernuth H, Grimbacher B. 2021. A Pathogenic Missense Variant in NFKB1 Causes Common Variable Immunodeficiency Due to Detrimental Protein Damage. Front Immunol. 12:621503.