The goal of the CRC 1160
The Collaborative Research Center (CRC) 1160. “Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)” is a research consortium of clinical and basic immunologists exploring the basis of diseases mediated by the immune system.
The CRC sets out to challenge the traditional idea that an “overreaction” or “deviation“ of normal immune responses is pivotal to immune mediated pathology and that, consequently, immunosuppression is the appropriate therapeutic strategy for such disorders. Instead, the conceptual basis of the CRC is the idea that impaired immune reactions constitute a major prerequisite for immunopathology. This is what we call the “IMPATH paradox”. This paradox implies that immune reconstitution and/or immune stimulation rather than immunosuppression represent appropriate therapeutic principles for these forms of immunopathology.
News
Publications
Faust, T. E., P. A. Feinberg, C. O’Connor, R. Kawaguchi, A. Chan, H. Strasburger, M. Frosch, M. A. Boyle, T. Masuda, L. Amann, K. P. Knobeloch, Prinz, A. Schaefer, and D. P. Schafer. 2023. A comparative analysis of microglial inducible Cre lines. Cell Rep 42: 113031. doi: 10.1016/j.celrep.2023.113031.
Alizadeh, Z., M. R. Fazlollahi, M. Mazinani, M. Badalzadeh, H. Heydarlou, R. Carapito, A. Molitor, A. C. G. de Oteyza, M. Proietti, M. S. Bavani, M. Shariat, M. Fallahpour, M. Movahedi, L. Moradi, B. Grimbacher, S. Bahram, and Z. Pourpak. 2023. Clinical, immunological and molecular findings of 8 patients with typical and atypical severe combined immunodeficiency: identification of 7 novel mutations by whole exome sequencing. Genes Immun 24: 207-214. doi: 10.1038/s41435-023-00215-w.
Eisenbeis, V. B., D. Qiu, O. Gorka, L. Strotmann, G. Liu, I. Prucker, X. B. Su, M. S. C. Wilson, K. Ritter, C. Loenarz, Gross, A. Saiardi, and H. J. Jessen. 2023. beta-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner. Proc Natl Acad Sci U S A 120: e2306868120.
Macpherson, A. J., V. Pachnis, and Prinz. 2023. Boundaries and integration between microbiota, the nervous system, and immunity. Immunity 56: 1712-1726. doi: 10.1016/j.immuni.2023.07.011.
Wolf C, Fischer H, Kühl JS, Koss S, Abou Jamra R, Starke S, Schultz J, Ehl S, Neumann K, Schuetz C, Huber R, Hornung V, Lee-Kirsch MA. 2023. Hemophagocytic lymphohistiocytosis-like hyperinflammation due to a de novo mutation in DPP9. J Allergy Clin Immunol. 2023 Aug 4:S0091-6749(23)00978-8. doi: 10.1016/j.jaci.2023.07.013.
Contact
Scientific Manager/Administration
Dr. Heike Ufheil
Institute for Immunodeficiency,
Center for Chronic Immunodeficiency (CCI)
Medical Center – University of Freiburg
