Center for Medicine
Department for Pathology
Institute for Surgical Pathology
Breisacher Str. 115A
79106 Freiburg
- +49 (0) 761 / 270-80650; -80400
- christoph.schell@uniklinik-freiburg.de
- Homepage
Current Position
Pathology Resident, Group Leader and Clinician-Scientist at the Institute of Surgical Pathology, Medical Center – University of Freiburg
Academic training
| 2011 - 2014 | PhD at SGBM graduate school, University of Freiburg |
| 2002 - 2008 | Medical School, LMU and TU Munich |
Scientific training
| 2020 | Habilitation in Experimental Pathology, University of Freiburg (Mentor: Prof. Dr. M. Werner & Prof. Dr. T. Huber) |
| 2014 | Dissertation (Dr. rer. nat.), Faculty of Biology, University of Freiburg (Supervisor: Prof. Dr. T. Huber) |
| 2012 | Dissertation (Dr. med.) LMU University of Munich (Supervisor: Prof. Dr. A. Mayrhofer) |
Postgraduate positions
| 2017 - present | Group Leader, Institute of Surgical Pathology, Medical Center - University of Freiburg |
| 2016 - present | Pathology Resident, Institute of Surgical Pathology, Medical Center - University of Freiburg |
| 2014 - 2015 | Junior Group Leader, Department of Nephrology, Medical Center - University of Freiburg |
| 2011 - 2015 | Reserach Fellow, Department of Nephrology, Medical Center - University of Freiburg |
| 2010- 2011 | Internal Medicine Residency, Medical Center - University of Freiburg |
| 2009 - 2010 | Internal Medicine Residency, Medical Center - University of Freiburg |
Miscellaneous (Honors, Awards)
| 2017 - 2020 | Berta-Ottenstein Clinician Scientist Fellow |
| 2014 | Research Stipend – German Society of Nephrology |
| 2013 - 2014 | Clinician Scientist Fellowship – NAKSYS (EKFS) |
link to all publications from C. Schell: Pubmed
Publications based on CRC1160 funding
Runge S, von Zedtwitz S, Maucher AM, Bruno P, Osbelt L, Zhao B, Gernand AM, Lesker TR, Gräwe K, Rogg M, Schell C, Boerries M, Strowig T, Andrieux G, Hild B, Rosshart SP. 2025. Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype. Nat Commun. 2025 Jun 12;16(1):5301. doi: 10.1038/s41467-025-60554-2.
Konwar S, Schroda S, Rogg M, Kleindienst J, Decker EL, Pohl M, Zieger B, Panse JP, Wang H, Grosse R, Schell C, Vidal S, Liu X, Gorzelanny C, Tschongov T, Häffner K. 2025. Thrombospondin-1 inhibits alternative complement pathway activation in antineutrophil cytoplasmic antibody-associated vasculitis. J Clin Invest. May 8:e180062. doi: 10.1172/JCI180062.
Wess M, Rogg M, Gueib-Picard C, Merz A, Kössinger AL, Feilen T, Andreev G, Werner M, Frew IJ, Grabbert M, Schilling O, Schell C. 2025. Versatile roles of annexin A4 in clear cell renal cell carcinoma: Impact on membrane repair, transcriptional signatures, and composition of the tumor microenvironment. iScience. 28(4):112198. doi: 10.1016/j.isci.2025.112198.
Andreev G, Vollmer T, Zirngibl M, Werner M, Grabbert M, Schilling O, Rogg M, Schell C. 2025. Spatial correlation of the extracellular matrix to immune cell phenotypes in the tumor boundary of ccRCC revealed by cyclic immunohistochemistry. Lab Invest. 2025 Mar 20:104130. doi: 10.1016/j.labinv.2025.104130.
Braun LM, Giesler S, Andrieux G, Riemer R, Talvard-Balland N, Duquesne S, Rückert T, Unger S, Kreutmair S, Zwick M, Follo M, Hartmann A, Osswald N, Melchinger W, Chapman S, Hutchinson JA, Haferkamp S, Torster L, Kött J, Gebhardt C, Hellwig D, Karantzelis N, Wallrabenstein T, Lowinus T, Yücel M, Brehm N, Rawluk J, Pfeifer D, Bronsert P, Rogg M, Mattern S, Heikenwälder M, Fusco S, Malek NP, Singer S, Schmitt-Graeff A, Ceteci F, Greten FR, Blazar BR, Boerries M, Köhler N, Duyster J, Ihorst G, Lassmann S, Keye P, Minguet S, Schadendorf D, Ugurel S, Rafei-Shamsabadi D, Thimme R, Hasselblatt P, Bengsch B, Schell C, Pearce EL, Meiss F, Becher B, Funke-Lorenz C, Placke JM, Apostolova P, Zeiser R. 2025. Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity. Cancer Cell. 2025 Feb 10;43(2):269-291.e19. doi: 10.1016/j.ccell.2025.01.004.
Mansoori Moghadam Z, Zhao B, Raynaud C RWTH University Hospital, Strohmeier V, Neuber J, Lösslein AK, Qureshi S, Gres V, Ziegelbauer T, Baasch S, Schell C, Warnatz K, Inohara N, Nunez G, Clavel T, Rosshart SP, Kolter J, Henneke P. 2025. Reactive oxygen species regulate early development of the intestinal macrophage-microbiome interface. Blood. blood.2024025240. doi: 10.1182/blood.2024025240.
Mann J, Runge S, Schell C, Gräwe K, Thoulass G, Lao J, Ammann S, Grün S, König C, Berger SA, Hild B, Aichele P, Rosshart SP, Ehl S. 2024. The Microbiome Modifies Manifestations of Hemophagocytic Lymphohistiocytosis in Perforin-Deficient Mice. Eur J Immunol. 2024 Nov 16:e202451061. doi: 10.1002/eji.202451061.
Arnold F, Kupferschmid L, Weissenborn P, Heldmann L, Hummel JF, Zareba P, Sagar, Rogg M, Schell C, Tanriver Y. 2024. Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis. Cell Mol Immunol. Jul 3. doi: 10.1038/s41423-024-01197-z.
Kögl T, Chang HF, Staniek J, Chiang SCC, Thoulass G, Lao J, Weißert K, Dettmer-Monaco V, Geiger K, Manna PT, Beziat V, Momenilandi M, Tu SM, Keppler SJ, Pattu V, Wolf P, Kupferschmid L, Tholen S, Covill LE, Ebert K, Straub T, Groß M, Gather R, Engel H, Salzer U, Schell C, Maier S, Lehmberg K, Cornu TI, Pircher H, Shahrooei M, Parvaneh N, Elling R, Rizzi M, Bryceson YT, Ehl S, Aichele P, Ammann S. 2024. Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect. J Exp Med. 221(7):e20221122. doi: 10.1084/jem.20221122.
Moeed A, Thilmany N, Beck F, Puthussery BK, Ortmann N, Haimovici A, Badr MT, Haghighi EB, Boerries M, Öllinger R, Rad R, Kirschnek S, Gentle IE, Donakonda S, Petric PP, Hummel JF, Pfaffendorf E, Zanetta P, Schell C, Schwemmle M, Weber A, Häcker G. 2024. The Caspase-Activated DNase drives inflammation and contributes to defense against viral infection. Cell Death Differ. 2024 Jun 7. doi: 10.1038/s41418-024-01320-7.
Dettmer-Monaco V, Weißert K, Ammann S, Monaco G, Lei L, Gräßel L, Rhiel M, Rositzka J, Kaufmann MM, Geiger K, Andrieux G, Lao J, Thoulass G, Schell C, Boerries M, Illert AL, Cornu TI, Ehl S, Aichele P, Cathomen T. 2024. Gene editing of hematopoietic stem cells restores T-cell response in familial hemophagocytic lymphohistiocytosis. J Allergy Clin Immunol. Jan;153(1):243-255.e14. doi: 10.1016/j.jaci.2023.08.003.
Rogg M, Maier JI, Helmstädter M, Sammarco A, Kliewe F, Kretz O, Weißer L, Van Wymersch C, Findeisen K, Koessinger AL, Tsoy O, Baumbach J, Grabbert M, Werner M, Huber TB, Endlich N, Schilling O, Schell C. 2023. A YAP/TAZ-ARHGAP29-RhoA Signaling Axis Regulates Podocyte Protrusions and Integrin Adhesions. Cells. 2023 Jul 6;12(13):1795. doi: 10.3390/cells12131795.
Strohmeier V, Andrieux G, Unger S, Pascual-Reguant A, Klocperk A, Seidl M, Marques OC, Eckert M, Gräwe K, Shabani M, von Spee-Mayer C, Friedmann D, Harder I, Gutenberger S, Keller B, Proietti M, Bulashevska A, Grimbacher B, Provaznik J, Benes V, Goldacker S, Schell C, Hauser AE, Boerries M, Hasselblatt P, Warnatz K. 2023. Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency-Associated Villous Atrophy and Norovirus Infection. J Clin Immunol. 43(2):371-390. doi: 10.1007/s10875-022-01379-2.
Ruckert, T., G. Andrieux, M. Boerries, K. Hanke-Muller, N. M. Woessner, S. Doetsch, C. Schell, K. Aumann, J. Kolter, A. Schmitt-Graeff, M. Schiff, L. M. Braun, E. Haring, S. Kissel, B. A. Siranosian, A. S. Bhatt, P. Nordkild, J. Wehkamp, B. A. H. Jensen, S. Minguet, J. Duyster, R. Zeiser, and N. Kohler. 2022. Human beta-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling. Sci Transl Med 14: eabp9675. doi: 10.1126/scitranslmed.abp9675.
Weissert, K., S. Ammann, T. Kogl, V. Dettmer-Monaco, C. Schell, T. Cathomen, S. Ehl, and P. Aichele. 2022. Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH). EMBO Mol Med: e16085. doi: 10.15252/emmm.202216085.
Strohmeier, V., G. Andrieux, S. Unger, A. Pascual-Reguant, A. Klocperk, M. Seidl, O. C. Marques, M. Eckert, K. Grawe, M. Shabani, C. von Spee-Mayer, D. Friedmann, I. Harder, S. Gutenberger, B. Keller, M. Proietti, A. Bulashevska, B. Grimbacher, J. Provaznik, V. Benes, S. Goldacker, C. Schell, A. E. Hauser, M. Boerries, P. Hasselblatt, and K. Warnatz. 2022. Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency-Associated Villous Atrophy and Norovirus Infection. J Clin Immunol. pii: 10.1007/s10875-022-01379-2. doi: 10.1007/s10875-022-01379-2.
Globig AM, Mayer LS, Heeg M, Andrieux G, Ku M, Otto-Mora P, Hipp A, Zoldan K, Pattekar A, Rana N, Schell C, Boerries M, Hofmann M, Neumann-Haefelin C, Kuellmer A, Schmidt A, Boettler T, Tomov V, Thimme R, Hasselblatt P, Bengsch B. Gastroenterology. 2022. Exhaustion of CD39-expressing CD8+ T cells in Crohn’s disease is linked to clinical outcome. First published: 2022 Jun 20:S0016-5085(22)00663-1. doi: 10.1053/j.gastro.2022.06.045. Online ahead of print.
