Klaus Warnatz

Prof. Dr.
Alumni

Department of Rheumatology and Clinical Immunology & Center for Chronic Immunodeficiency (CCI)
Medical Center – University of Freiburg

Breisacher Str. 115
79106 Freiburg i. Brsg.

Current position

Apl. Professor, attending physician and Group leader, Center for Chronic Immunodeficiency and Department of Rheumatology and Clinical Immunology, Center for Medicine,
Medical Center – University of Freiburg

Academic training

1984 – 1991 Study of Medicine in Aachen

Scientific qualifications

2006 Habilitation in Rheumatology/Internal Medicine,
University of Freiburg (Mentor: Prof. H.H. Peter)
1992 Dissertation in Medicine, RWTH Aachen
(Supervisor: Prof. S. Markos-Pusztai)

Postgraduate Positions

since 2008 Attending physician, CCI, Freiburg (Apl. Prof. of Clinical Immunology)
since 2006 Attending physician, Division of Rheumatology and Clinical Immunology, Department of Internal Medicine,
Medical Center - University of Freiburg
1999 – 2006 Resident, Division of Rheumatology and Clinical Immunology, Medical Center – University of Freiburg
1997 – 1999 Postdoctorate, Clinical Research Group Rheumatology, Freiburg
1994 – 1997 Postdoctorate, UCSD, San Diego, USA
1992 – 1994 Resident, Intensive Care/Toxicology, Klinikum Rechts der Isar, Munich

link to all publications from K. Warnatz: Pubmed

Publications based on CRC1160 funding

Staniek J, Kalina T, Andrieux G, Boerries M, Janowska I, Fuentes M, Díez P, Bakardjieva M, Stancikova J, Raabe J, Neumann J, Schwenk S, Arpesella L, Stuchly J, Benes V, García Valiente R, Fernández García J, Carsetti R, Piano Mortari E, Catala A, de la Calle O, Sogkas G, Neven B, Rieux-Laucat F, Magerus A, Neth O, Olbrich P, Voll RE, Alsina L, Allende LM, Gonzalez-Granado LI, Böhler C, Thiel J, Venhoff N, Lorenzetti R, Warnatz K, Unger S, Seidl M, Mielenz D, Schneider P, Ehl S, Rensing-Ehl A, Smulski CR, Rizzi M. 2024. Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells. Sci Immunol. Jan 12;9(91):eadj5948. doi: 10.1126/sciimmunol.adj5948.

Keller B, Kfir-Erenfeld S, Matusewicz P, Hartl F, Lev A, Lee YN, Simon AJ, Stauber T, Elpeleg O, Somech R, Stepensky P, Minguet S, Schraven B, Warnatz K. 2024. Combined Immunodeficiency Caused by a Novel Nonsense Mutation in LCK. J Clin Immunol. 44(1):4. doi: 10.1007/s10875-023-01614-4.

Uzel, G., B. Keller, and K. Warnatz. 2023. Hypogammaglobulinemia and immune dysregulation – not just two sides of a coin. J Allergy Clin Immunol. doi:10.1016/j.jaci.2023.11.005.

Rensing-Ehl, A., M. R. Lorenz, M. Fuhrer, W. Willenbacher, E. Willenbacher, S. Sopper, M. Abinun, M. E. Maccari, C. Konig, P. Haegele, S. Fuchs, C. Castro, P. Kury, O. Pelle, C. Klemann, M. Heeg, J. Thalhammer, O. Wegehaupt, M. Fischer, S. Goldacker, B. Schulte, S. Biskup, P. Chatelain, V. Schuster, K. Warnatz, B. Grimbacher, A. Meinhardt, D. Holzinger, P. T. Oommen, T. Hinze, H. Hebart, K. Seeger, K. Lehmberg, T. R. Leahy, A. Claviez, S. Vieth, F. H. Schilling, I. Fuchs, M. Gross, F. Rieux-Laucat, A. Magerus, C. Speckmann, K. Schwarz, S. Ehl, and A. s. group. 2023. Abnormal biomarkers predict complex FAS or FADD defects missed by exome sequencing. J Allergy Clin Immunol. doi:10.1016/j.jaci.2023.11.006.

Maccari ME, Wolkewitz M, Schwab C, Lorenzini T, Leiding JW, Aladjdi N, Abolhassani H, Abou-Chahla W, Aiuti A, Azarnoush S, Baris S, Barlogis V, Barzaghi F, Baumann U, Bloomfield M, Bohynikova N, Bodet D, Boutboul D, Bucciol G, Buckland MS, Burns SO, Cancrini C, Cathébras P, Cavazzana M, Cheminant M, Chinello M, Ciznar P, Coulter TI, D’Aveni M, Ekwall O, Eric Z, Eren E, Fasth A, Frange P, Fournier B, Garcia-Prat M, Gardembas M, Geier C, Ghosh S, Goda V, Hammarström L, Hauck F, Heeg M, Heropolitanska-Pliszka E, Hilfanova A, Jolles S, Karakoc-Aydiner E, Kindle GR, Kiykim A, Klemann C, Koletsi P, Koltan S, Kondratenko I, Körholz J, Krüger R, Jeziorski E, Levy R, Le Guenno G, Lefevre G, Lougaris V, Marzollo A, Mahlaoui N, Malphettes M, Meinhardt A, Merlin E, Meyts I, Milota T, Moreira F, Moshous D, Mukhina A, Neth O, Neubert J, Neven B, Nieters A, Nove-Josserand R, Oksenhendler E, Ozen A, Olbrich P, Perlat A, Pac M, Schmid JP, Pacillo L, Parra-Martinez A, Paschenko O, Pellier I, Sefer AP, Plebani A, Plantaz D, Prader S, Raffray L, Ritterbusch H, Riviere JG, Rivalta B, Rusch S, Sakovich I, Savic S, Scheible R, Schleinitz N, Schuetz C, Schulz A, Sediva A, Semeraro M, Sharapova SO, Shcher…See abstract for full author list. 2023. Activated phosphoinositide 3-kinase δ syndrome: Update from the ESID Registry and comparison with other autoimmune-lymphoproliferative inborn errors of immunity. J Allergy Clin Immunol. Oct;152(4):984-996.e10. doi: 10.1016/j.jaci.2023.06.015.

Smits, B., S. Goldacker, S. Seneviratne, M. Malphettes, H. Longhurst, O. E. Mohamed, C. Witt-Rautenberg, L. Leeman, E. Schwaneck, I. Raymond, K. Meghit, A. Uhlmann, C. Winterhalter, J. van Montfrans, M. Klima, S. Workman, C. Fieschi, L. Lorenzo, S. Boyle, S. Onyango-Odera, S. Price, M. Schmalzing, V. Aurillac, A. Prasse, I. Hartmann, J. J. Meerburg, M. Kemner-van de Corput, H. Tiddens, B. Grimbacher, P. Kelleher, S. Y. Patel, A. S. Korganow, J. F. Viallard, H. P. Tony, C. Bethune, H. Schulze-Koops, T. Witte, A. Huissoon, H. Baxendale, S. Grigoriadou, E. Oksenhendler, S. O. Burns, and K. Warnatz. 2023. The efficacy and safety of systemic corticosteroids as first line treatment for granulomatous lymphocytic interstitial lung disease. J Allergy Clin Immunol 152: 528-537. doi: 10.1016/j.jaci.2022.12.813.

Staus P, Rusch S, El-Helou S, Müller G, Krausz M, Geisen U, Caballero-Oteyza A, Krüger R, Bakhtiar S, Lee-Kirsch MA, Fasshauer M, Baumann U, Hoyer BF, Farela Neves J, Borte M, Carrabba M, Hauck F, Ehl S, Bader P, von Bernuth H, Atschekzei F, Seppänen MRJ, Warnatz K, Nieters A, Kindle G, Grimbacher B. 2023.  The GAIN Registry – a New Prospective Study for Patients with Multi-organ Autoimmunity and Autoinflammation. J Clin Immunol. Apr 21:1-13. doi: 10.1007/s10875-023-01472-0.

Lim YW, Ramirez NJ, Asensio MA, Chiang Y, Müller G, Mrovecova P, Mitsuiki N, Krausz M, Camacho-Ordonez N, Warnatz K, Adler AS, Grimbacher B. 2023. Sequencing the B Cell Receptor Repertoires of Antibody-Deficient Individuals With and Without Infection Susceptibility.  J Clin Immunol. Feb 24. doi: 10.1007/s10875-023-01448-0.

Strohmeier V, Andrieux G, Unger S, Pascual-Reguant A, Klocperk A, Seidl M, Marques OC, Eckert M, Gräwe K, Shabani M, von Spee-Mayer C, Friedmann D, Harder I, Gutenberger S, Keller B, Proietti M, Bulashevska A, Grimbacher B, Provaznik J, Benes V, Goldacker S, Schell C, Hauser AE, Boerries M, Hasselblatt P, Warnatz K. 2023. Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency-Associated Villous Atrophy and Norovirus Infection. J Clin Immunol. 43(2):371-390. doi: 10.1007/s10875-022-01379-2.

Globig, A. M., V. Strohmeier, R. Surabattula, D. J. Leeming, M. A. Karsdal, M. Heeg, G. Kindle, S. Goldacker, C. von Spee-Mayer, M. Proietti, B. Bausch, D. Bettinger, M. Schultheiss, R. Thimme, D. Schuppan, and K. Warnatz. 2022. Evaluation of Laboratory and Sonographic Parameters for Detection of Portal Hypertension in Patients with Common Variable Immunodeficiency. J Clin Immunol. pii: 10.1007/s10875-022-01319-0. doi: 10.1007/s10875-022-01319-0.

Strohmeier, V., G. Andrieux, S. Unger, A. Pascual-Reguant, A. Klocperk, M. Seidl, O. C. Marques, M. Eckert, K. Grawe, M. Shabani, C. von Spee-Mayer, D. Friedmann, I. Harder, S. Gutenberger, B. Keller, M. Proietti, A. Bulashevska, B. Grimbacher, J. Provaznik, V. Benes, S. Goldacker, C. Schell, A. E. Hauser, M. Boerries, P. Hasselblatt, and K. Warnatz. 2022. Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency-Associated Villous Atrophy and Norovirus Infection. J Clin Immunol. pii: 10.1007/s10875-022-01379-2. doi: 10.1007/s10875-022-01379-2.

Leiding, J. W., T. P. Vogel, V. G. J. Santarlas, R. Mhaskar, M. R. Smith, A. Carisey, A. Vargas-Hernandez, M. Silva-Carmona, M. Heeg, A. Rensing-Ehl, B. Neven, J. Hadjadj, S. Hambleton, T. Ronan Leahy, K. Meesilpavikai, C. Cunningham-Rundles, C. M. Dutmer, S. O. Sharapova, M. Taskinen, I. Chua, R. Hague, C. Klemann, L. Kostyuchenko, T. Morio, A. Thatayatikom, A. Ozen, A. Scherbina, C. S. Bauer, S. E. Flanagan, E. Gambineri, L. Giovannini-Chami, J. Heimall, K. E. Sullivan, E. Allenspach, N. Romberg, S. G. Deane, B. T. Prince, M. J. Rose, J. Bohnsack, T. Mousallem, R. Jesudas, M. M. D. Santos Vilela, M. O’Sullivan, J. Pachlopnik Schmid, S. Pruhova, A. Klocperk, M. Rees, H. Su, S. Bahna, S. Baris, L. M. Bartnikas, A. Chang Berger, T. A. Briggs, S. Brothers, V. Bundy, A. Y. Chan, S. Chandrakasan, M. Christiansen, T. Cole, M. C. Cook, M. M. Desai, U. Fischer, D. A. Fulcher, S. Gallo, A. Gauthier, A. R. Gennery, J. Goncalo Marques, F. Gottrand, B. Grimbacher, E. Grunebaum, E. Haapaniemi, S. Hamalainen, K. Heiskanen, T. Heiskanen-Kosma, H. M. Hoffman, L. I. Gonzalez-Granado, A. L. Guerrerio, L. Kainulainen, A. Kumar, M. G. Lawrence, C. Levin, T. Martelius, O. Neth, P. Olbrich, A. Palma, N. C. Patel, T. Pozos, K. Preece, S. O. Lugo Reyes, M. A. Russell, Y. Schejter, C. Seroogy, J. Sinclair, E. Skevofilax, D. Suan, D. Suegeorgz, P. Szabolcs, H. Velasco, K. Warnatz, K. Walkovich, A. Worth, S. G. W. G. members, M. R. J. Seppanen, T. R. Torgerson, G. Sogkas, S. Ehl, S. G. Tangye, M. A. Cooper, J. D. Milner, and L. R. Forbes Satter. 2022. Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome. J Allergy Clin Immunol. pii: S0091-6749(22)01182-4. doi: 10.1016/j.jaci.2022.09.002.

Krausz, M., A. Uhlmann, I. C. Rump, G. Ihorst, S. Goldacker, G. Sogkas, S. Posadas-Cantera, R. Schmidt, M. Feisst, L. Alsina, I. Dybedal, M. Recher, Warnatz, and B. Grimbacher. 2022. The ABACHAI clinical trial protocol: Safety and efficacy of abatacept (s.c.) in patients with CTLA-4 insufficiency or LRBA deficiency: A non controlled phase 2 clinical trial. Contemp Clin Trials Commun 30: 101008. doi: 10.1016/j.conctc.2022.101008.

Fliegauf, M., M. Kinnunen, S. Posadas-Cantera, N. Camacho-Ordonez, H. Abolhassani, L. Alsina, F. Atschekzei, D. J. Bogaert, S. O. Burns, J. A. Church, G. Duckers, A. F. Freeman, L. Hammarstrom, L. G. Hanitsch, T. Kerre, R. Kobbe, S. O. Sharapova, K. Siepermann, C. Speckmann, S. Steiner, N. Verma, J. E. Walter, E. Westermann-Clark, S. Goldacker, K. Warnatz, M. Varjosalo, and B. Grimbacher. 2022. Detrimental NFKB1 missense variants affecting the Rel-homology domain of p105/p50. Front Immunol 13: 965326. doi: 10.3389/fimmu.2022.965326.

Ramirez, N., S. Posadas-Cantera, N. Langer, A. C. G. de Oteyza, M. Proietti, B. Keller, F. Zhao, V. Gernedl, M. Pecoraro, H. Eibel, K. Warnatz, E. Ballestar, R. Geiger, C. Bossen, and B. Grimbacher. 2022. Multi-omics analysis of naive B cells of patients harboring the C104R mutation in TACI. Front Immunol 13: 938240. doi: 10.3389/fimmu.2022.938240.

Kemming, J., S. Gundlach, M. Panning, D. Huzly, J. Huang, M. Lutgehetmann, S. Pischke, J. Schulze Zur Wiesch, F. Emmerich, S. Llewellyn-Lacey, D. A. Price, Y. Tanriver, K. Warnatz, T. Boettler, R. Thimme, M. Hofmann, N. Fischer, and C. Neumann-Haefelin. 2022. Mechanisms of CD8+ T-cell failure in chronic hepatitis E virus infection. J Hepatol 77: 978-990. doi: 10.1016/j.jhep.2022.05.019.

Gross, M., C. Speckmann, A. May, T. Gajardo-Carrasco, K. Wustrau, S. L. Maier, M. Panning, D. Huzly, A. Agaimy, Y. T. Bryceson, S. Choo, C. W. Chow, G. Duckers, A. Fasth, S. Fraitag, K. Grawe, S. Haxelmans, D. Holzinger, O. Hudowenz, J. M. Hubschen, C. Khurana, K. Kienle, R. Klifa, K. Korn, H. Kutzner, T. Lammermann, S. Ledig, D. Lipsker, M. Meeths, N. Naumann-Bartsch, J. Rascon, A. Schanzer, M. Seidl, B. Tesi, C. Vauloup-Fellous, B. Vollmer-Kary, K. Warnatz, C. Wehr, B. Neven, P. Vargas, F. E. Sepulveda, K. Lehmberg, A. Schmitt-Graeff, and S. Ehl. 2022. Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity. J Allergy Clin Immunol 149: 388-399.e4. doi: 10.1016/j.jaci.2021.05.007.

Klocperk A, Friedmann D, Schlaak AE, Unger S, Parackova Z, Goldacker S, Sediva A, Bengsch B, Warnatz K. 2022. Distinct CD8 T Cell Populations with Differential Exhaustion Profiles Associate with Secondary Complications in Common Variable Immunodeficiency. J Clin Immunol, First published: 2022 May 19. doi: 10.1007/s10875-022-01291-9.

Zeiser R, Warnatz K, Rosshart S, Sagar, Tanriver Y. 2022. GVHD, IBD and primary immunodeficiencies: The gut as a target of immunopathology resulting from impaired immunity. Eur J Immunol. 52(9):1406-1418. doi: 10.1002/eji.202149530.

Harder, I., M. Munchhalfen, G. Andrieux, Boerries, B. Grimbacher, H. Eibel, M. E. Maccari, S. Ehl, J. Wienands, J. Jellusova, K. Warnatz, and B. Keller. 2022. Dysregulated PI3K Signaling in B Cells of CVID Patients. Cells 11:464. doi: 10.3390/cells11030464.

Rojas-Restrepo J, Caballero-Oteyza A, Huebscher K, Haberstroh H, Fliegauf M, Keller B, Kobbe R, Warnatz K, Ehl S, Proietti M, Grimbacher B. 2021. Establishing the Molecular Diagnoses in a Cohort of 291 Patients With Predominantly Antibody Deficiency by Targeted Next-Generation Sequencing: Experience From a Monocentric Study. Front Immunol. 12:786516. doi: 10.3389/fimmu.2021.786516.

Volk T, Warnatz K, Marks R, Urbach H, Schluh G, Strohmeier V, Rojas-Restrepo J, Grimbacher B, Rauer S. 2021. Pembrolizumab for treatment of progressive multifocal leukoencephalopathy in primary immunodeficiency and/or hematologic malignancy: a case series of five patients. J Neurol. 2021 Jul 1. doi: 10.1007/s00415-021-10682-8.

Wang, L., D. Aschenbrenner, Z. Zeng, X. Cao, D. Mayr, M. Mehta, M. Capitani, N. Warner, J. Pan, L. Wang, Q. Li, T. Zuo, S. Cohen-Kedar, J. Lu, R. C. Ardy, D. J. Mulder, D. Dissanayake, K. Peng, Z. Huang, X. Li, Y. Wang, X. Wang, S. Li, S. Bullers, A. N. Gammage, K. Warnatz, A. I. Schiefer, G. Krivan, V. Goda, W. H. A. Kahr, M. Lemaire, C. Genomics England Research, C. Y. Lu, I. Siddiqui, M. G. Surette, D. Kotlarz, K. R. Engelhardt, H. R. Griffin, R. Rottapel, H. Decaluwe, R. M. Laxer, M. Proietti, S. Hambleton, S. Elcombe, C. H. Guo, B. Grimbacher, I. Dotan, S. C. Ng, S. A. Freeman, S. B. Snapper, C. Klein, K. Boztug, Y. Huang, D. Li, H. H. Uhlig, and A. M. Muise. 2021. Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice. Nat Genet 53: 500-510.

Globig, A. M., M. Heeg, C. S. Larsen, R. D. Ferreira, G. Kindle, S. Goldacker, V. Strohmeier, S. L. Silva, C. Cunningham-Rundles, I. Quinti, R. Thimme, D. Bettinger, M. Schultheiss, and K. Warnatz. 2021. International multicenter experience of transjugular intrahepatic portosystemic shunt implantation in patients with common variable immunodeficiency. J Allergy Clin Immunol Pract. 13:S2213-2198(21)00301-9.

Maccari, M. E., S. Fuchs, P. Kury, G. Andrieux, S. Volkl, B. Bengsch, M. R. Lorenz, M. Heeg, J. Rohr, S. Jagle, C. N. Castro, M. Gross, U. Warthorst, C. Konig, I. Fuchs, C. Speckmann, J. Thalhammer, F. G. Kapp, M. G. Seidel, G. Duckers, S. Schonberger, C. Schutz, M. Fuhrer, R. Kobbe, D. Holzinger, C. Klemann, P. Smisek, S. Owens, G. Horneff, R. Kolb, N. Naumann-Bartsch, M. Miano, J. Staniek, M. Rizzi, T. Kalina, P. Schneider, A. Erxleben, R. Backofen, A. Ekici, C. M. Niemeyer, K. Warnatz, B. Grimbacher, H. Eibel, A. Mackensen, A. P. Frei, K. Schwarz, M. Boerries, S. Ehl, and A. Rensing-Ehl. 2021. A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS. J Exp Med 218(2):e20192191. doi: 10.1084/jem.20192191.

Basho K, Zoldan K, Schultheiss M, Bettinger D, Globig AM, Bengsch B, Neumann-Haefelin C, Klocperk A, Warnatz K, Hofmann M, Thimme R, Boettler T. 2020. IL-2 contributes to cirrhosis-associated immune dysfunction by impairing follicular T helper cells in advanced cirrhosis. J Hepatol. S0168-8278(20)33692-8. doi: 10.1016/j.jhep.2020.10.012.

Klocperk, A., S. Unger, D. Friedmann, M.  Seidl, K. Zoldan, J. Pfeiffer, O. Hausmann, V. Benes, G. Andrieux, T. Boettler, A. Sediva, B. Bengsch, and K. Warnatz. 2020. Exhausted phenotype of follicular CD8 T cells in CVID. J Allergy Clin Immunol. pii: S0091-6749(20)30333-X. doi: 10.1016/j.jaci.2020.02.025. [Epub ahead of print]

Troilo, A., C. Wehr, I. Janowska, N. Venhoff, J. Thiel, J. Rawluk, N. Frede, J. Staniek, R. Lorenzetti, M. T. Schleyer, G. W. Herget, L. Konstantinidis, M. Erlacher, M. Proietti, N. Camacho-Ordonez, R. E. Voll, B. Grimbacher, K. Warnatz, U. Salzer, and M. Rizzi. 2020. Nonpermissive bone marrow environment impairs early B-cell development in common variable immunodeficiency. Blood 135: 1452-1457.

van de Ven A, Mader I, Wolff D, Goldacker S, Fuhrer H, Rauer S, Grimbacher B, Warnatz K. 2019. Structural non-infectious manifestations of the central nervous system in common variable immunodeficiency disorders. J Allergy Clin Immunol Pract. pii: S2213-2198(19)31026-8.

Staniek J, Lorenzetti R, Heller B, Janowska I, Schneider P, Unger S, Warnatz K, Seidl M, Venhoff N, Thiel J, Smulski CR, Rizzi M. 2019. TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes. Front Immunol. 10:951.

von Spee-Mayer, C., V. Koemm, C. Wehr, S. Goldacker, G. Kindle, A. Bulashevska, M. Proietti, Grimbacher, S. Ehl, and K. Warnatz. 2019. Evaluating laboratory criteria for combined immunodeficiency in adult patients diagnosed with common variable immunodeficiency. Clin Immunol. 203:59-62.

Eskandarian, Z., M. Fliegauf, A. Bulashevska, M. Proietti, R. Hague, C. R. Smulski, D. Schubert, Warnatz, and B. Grimbacher. 2019. Assessing the Functional Relevance of Variants in the IKAROS Family Zinc Finger Protein 1 (IKZF1) in a Cohort of Patients With Primary Immunodeficiency. Front Immunol 10: 568.

Klemann C, Camacho-Ordonez N, Yang L, Eskandarian Z, Rojas-Restrepo JL, Frede N, Bulashevska A, Heeg M, Al-Ddafari MS, Premm J, Seidl M, Ammann S, Sherkat R, Radhakrishnan N, Warnatz K, Unger S, Kobbe R, Hüfner A, Leahy TR, Ip W, Burns SO, Fliegauf M, Grimbacher B. 2019. Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2. Front Immunol. 10:297.

Egg, D., C. Schwab, A. Gabrysch, P. D. Arkwright, E. Cheesman, L. Giulino-Roth, O. Neth, S. Snapper, S. Okada, M. Moutschen, P. Delvenne, A. C. Pecher, D. Wolff, Y. J. Kim, S. Seneviratne, K. M. Kim, J. M. Kang, S. Ojaimi, C. McLean, Warnatz, M. Seidl, and B. Grimbacher. 2018. Increased Risk for Malignancies in 131 Affected CTLA4 Mutation Carriers. Front Immunol 9: 2012.

Schwab, C., A. Gabrysch, P. Olbrich, V. Patino, Warnatz, D. Wolff, A. Hoshino, M. Kobayashi, K. Imai, M. Takagi, I. Dybedal, J. A. Haddock, D. Sansom, J. M. Lucena, M. Seidl, A. Schmitt-Graff, V. Reiser, F. Emmerich, N. Frede, A. Bulashevska, U. Salzer, D. Schubert, S. Hayakawa, S. Okada, M. Kanariou, Z. Y. Kucuk, H. Chapdelaine, L. Petruzelkova, Z. Sumnik, A. Sediva, M. Slatter, P. D. Arkwright, A. Cant, H. M. Lorenz, T. Giese, V. Lougaris, A. Plebani, C. Price, K. E. Sullivan, M. Moutschen, J. Litzman, T. Freiberger, F. L. van de Veerdonk, M. Recher, M. H. Albert, F. Hauck, S. Seneviratne, J. P. Schmid, A. Kolios, G. Unglik, C. Klemann, C. Speckmann, S. Ehl, A. Leichtner, R. Blumberg, A. Franke, S. Snapper, S. Zeissig, C. Cunningham-Rundles, L. Giulino-Roth, O. Elemento, G. Duckers, T. Niehues, E. Fronkova, V. Kanderova, C. D. Platt, J. Chou, T. Chatila, R. Geha, E. McDermott, S. Bunn, M. Kurzai, A. Schulz, L. Alsina, F. Casals, A. Deya-Martinez, S. Hambleton, H. Kanegane, K. Tasken, O. Neth, and B. Grimbacher. 2018. Phenotype, penetrance, and treatment of 133 CTLA-4-insufficient individuals. J Allergy Clin Immunol. 142: 1932-1946.

Friedmann, D., B. Keller, I. Harder, J. Schupp, Tanriver, S. Unger, and K. Warnatz. 2017. Preferential Reduction of Circulating Innate Lymphoid Cells Type 2 in Patients with Common Variable Immunodeficiency with Secondary Complications Is Part of a Broader Immune Dysregulation. J Clin Immunol 37: 759-769.

de Melo KM, Unger S, Keller B, Gutenberger S, Stumpf I, Goldacker S, Warnatz K. 2017. Increase of circulating α4β7(+) conventional memory CD4 and regulatory T cells in patients with common variable immunodeficiency (CVID). Clin Immunol. 180:80-83.