Klaus Warnatz

Principal Investigator

Department of Rheumatology and Clinical Immunology & Center for Chronic Immunodeficiency (CCI)
Medical Center – University of Freiburg

Breisacher Str. 115
79106 Freiburg i. Brsg.

Current position

Apl. Professor, attending physician and Group leader, Center for Chronic Immunodeficiency and Department of Rheumatology and Clinical Immunology, Center for Medicine,
Medical Center – University of Freiburg

Academic training

1984 – 1991 Study of Medicine in Aachen

Scientific qualifications

2006 Habilitation in Rheumatology/Internal Medicine,
University of Freiburg (Mentor: Prof. H.H. Peter)
1992 Dissertation in Medicine, RWTH Aachen
(Supervisor: Prof. S. Markos-Pusztai)

Postgraduate Positions

since 2008 Attending physician, CCI, Freiburg (Apl. Prof. of Clinical Immunology)
since 2006 Attending physician, Division of Rheumatology and Clinical Immunology, Department of Internal Medicine,
Medical Center - University of Freiburg
1999 – 2006 Resident, Division of Rheumatology and Clinical Immunology, Medical Center – University of Freiburg
1997 – 1999 Postdoctorate, Clinical Research Group Rheumatology, Freiburg
1994 – 1997 Postdoctorate, UCSD, San Diego, USA
1992 – 1994 Resident, Intensive Care/Toxicology, Klinikum Rechts der Isar, Munich

link to all publications from K. Warnatz: Pubmed

Publications based on CRC1160 funding

Basho K, Zoldan K, Schultheiss M, Bettinger D, Globig AM, Bengsch B, Neumann-Haefelin C, Klocperk A, Warnatz K, Hofmann M, Thimme R, Boettler T. 2020. IL-2 contributes to cirrhosis-associated immune dysfunction by impairing follicular T helper cells in advanced cirrhosis. J Hepatol. S0168-8278(20)33692-8. doi: 10.1016/j.jhep.2020.10.012.

Klocperk, A., S. Unger, D. Friedmann, M.  Seidl, K. Zoldan, J. Pfeiffer, O. Hausmann, V. Benes, G. Andrieux, T. Boettler, A. Sediva, B. Bengsch, and K. Warnatz. 2020. Exhausted phenotype of follicular CD8 T cells in CVID. J Allergy Clin Immunol. pii: S0091-6749(20)30333-X. doi: 10.1016/j.jaci.2020.02.025. [Epub ahead of print]

Troilo, A., C. Wehr, I. Janowska, N. Venhoff, J. Thiel, J. Rawluk, N. Frede, J. Staniek, R. Lorenzetti, M. T. Schleyer, G. W. Herget, L. Konstantinidis, M. Erlacher, M. Proietti, N. Camacho-Ordonez, R. E. Voll, B. Grimbacher, K. Warnatz, U. Salzer, and M. Rizzi. 2020. Nonpermissive bone marrow environment impairs early B-cell development in common variable immunodeficiency. Blood 135: 1452-1457.

van de Ven A, Mader I, Wolff D, Goldacker S, Fuhrer H, Rauer S, Grimbacher B, Warnatz K. 2019. Structural non-infectious manifestations of the central nervous system in common variable immunodeficiency disorders. J Allergy Clin Immunol Pract. pii: S2213-2198(19)31026-8.

Staniek J, Lorenzetti R, Heller B, Janowska I, Schneider P, Unger S, Warnatz K, Seidl M, Venhoff N, Thiel J, Smulski CR, Rizzi M. 2019. TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes. Front Immunol. 10:951.

von Spee-Mayer, C., V. Koemm, C. Wehr, S. Goldacker, G. Kindle, A. Bulashevska, M. Proietti, Grimbacher, S. Ehl, and K. Warnatz. 2019. Evaluating laboratory criteria for combined immunodeficiency in adult patients diagnosed with common variable immunodeficiency. Clin Immunol. 203:59-62.

Eskandarian, Z., M. Fliegauf, A. Bulashevska, M. Proietti, R. Hague, C. R. Smulski, D. Schubert, Warnatz, and B. Grimbacher. 2019. Assessing the Functional Relevance of Variants in the IKAROS Family Zinc Finger Protein 1 (IKZF1) in a Cohort of Patients With Primary Immunodeficiency. Front Immunol 10: 568.

Klemann C, Camacho-Ordonez N, Yang L, Eskandarian Z, Rojas-Restrepo JL, Frede N, Bulashevska A, Heeg M, Al-Ddafari MS, Premm J, Seidl M, Ammann S, Sherkat R, Radhakrishnan N, Warnatz K, Unger S, Kobbe R, Hüfner A, Leahy TR, Ip W, Burns SO, Fliegauf M, Grimbacher B. 2019. Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2. Front Immunol. 10:297.

Egg, D., C. Schwab, A. Gabrysch, P. D. Arkwright, E. Cheesman, L. Giulino-Roth, O. Neth, S. Snapper, S. Okada, M. Moutschen, P. Delvenne, A. C. Pecher, D. Wolff, Y. J. Kim, S. Seneviratne, K. M. Kim, J. M. Kang, S. Ojaimi, C. McLean, Warnatz, M. Seidl, and B. Grimbacher. 2018. Increased Risk for Malignancies in 131 Affected CTLA4 Mutation Carriers. Front Immunol 9: 2012.

Schwab, C., A. Gabrysch, P. Olbrich, V. Patino, Warnatz, D. Wolff, A. Hoshino, M. Kobayashi, K. Imai, M. Takagi, I. Dybedal, J. A. Haddock, D. Sansom, J. M. Lucena, M. Seidl, A. Schmitt-Graff, V. Reiser, F. Emmerich, N. Frede, A. Bulashevska, U. Salzer, D. Schubert, S. Hayakawa, S. Okada, M. Kanariou, Z. Y. Kucuk, H. Chapdelaine, L. Petruzelkova, Z. Sumnik, A. Sediva, M. Slatter, P. D. Arkwright, A. Cant, H. M. Lorenz, T. Giese, V. Lougaris, A. Plebani, C. Price, K. E. Sullivan, M. Moutschen, J. Litzman, T. Freiberger, F. L. van de Veerdonk, M. Recher, M. H. Albert, F. Hauck, S. Seneviratne, J. P. Schmid, A. Kolios, G. Unglik, C. Klemann, C. Speckmann, S. Ehl, A. Leichtner, R. Blumberg, A. Franke, S. Snapper, S. Zeissig, C. Cunningham-Rundles, L. Giulino-Roth, O. Elemento, G. Duckers, T. Niehues, E. Fronkova, V. Kanderova, C. D. Platt, J. Chou, T. Chatila, R. Geha, E. McDermott, S. Bunn, M. Kurzai, A. Schulz, L. Alsina, F. Casals, A. Deya-Martinez, S. Hambleton, H. Kanegane, K. Tasken, O. Neth, and B. Grimbacher. 2018. Phenotype, penetrance, and treatment of 133 CTLA-4-insufficient individuals. J Allergy Clin Immunol. 142: 1932-1946.

Friedmann, D., B. Keller, I. Harder, J. Schupp, Tanriver, S. Unger, and K. Warnatz. 2017. Preferential Reduction of Circulating Innate Lymphoid Cells Type 2 in Patients with Common Variable Immunodeficiency with Secondary Complications Is Part of a Broader Immune Dysregulation. J Clin Immunol 37: 759-769.

de Melo KM, Unger S, Keller B, Gutenberger S, Stumpf I, Goldacker S, Warnatz K. 2017. Increase of circulating α4β7(+) conventional memory CD4 and regulatory T cells in patients with common variable immunodeficiency (CVID). Clin Immunol. 180:80-83.