Martin Schwemmle

Principal Investigator

Department for Microbiology, Virology and Hygiene
Institute for Virology
Medical Center – University of Freiburg

Hermann Herder Str. 11
79104 Freiburg i. Brsg.

Current position

Professor, Institute for Virology, Department for Microbiology, Virology and Hygiene, Medical Center – University of Freiburg

Academic training

1983 – 1989 Study of Biology in Freiburg

Scientific qualifications

2000 Habilitation in Virology, University of Freiburg
(Mentor: Prof. Dr. Otto Haller)
1992 PhD Thesis, Faculty of Biology, University of Freiburg
(Supervisor: Prof. Dr. Kurt Hilse)

Postgraduate Positions

since 2003 Professor, Institute for Virology, Department for Microbiology, Virology and Hygiene, Medical Center - University of Freiburg
2002 – 2003 Group leader, Institute of Virology, University of Zurich, Switzerland
1997 – 2001 Group leader, Institute for Virology, Center for Microbiology and Hygiene, Medical Center - University of Freiburg
1995 – 1997 Postdoctorate, Institute of Neurology, University of California, Irvine, USA
1992 – 1995 Postdoctorate, Institute for Virology, Center for Microbiology and Hygiene, Medical Center - University of Freiburg

Miscellaneous (Honors, Awards)

1992 Hans-Griesebach Award for PhD Thesis

link to all publications from M. Schwemmle: Pubmed

Publications based on CRC1160 funding

Schulien I, Kemming J, Oberhardt V, Wild K, Seidel LM, Killmer S, Sagar, Daul F, Salvat Lago M, Decker A, Luxenburger H, Binder B, Bettinger D, Sogukpinar O, Rieg S, Panning M, Huzly D, Schwemmle M, Kochs G, Waller CF, Nieters A, Duerschmied D, Emmerich F, Mei HE, Schulz AR, Llewellyn-Lacey S, Price DA, Boettler T, Bengsch B, Thimme R, Hofmann M, Neumann-Haefelin C. 2020. Characterization of pre-existing and induced SARS-CoV-2-specific CD8 + T cells. Nat Med. 12. doi: 10.1038/s41591-020-01143-2.

Tran V, Ledwith MP, Thamamongood T, Higgins CA, Tripathi S, Chang MW, Benner C, García-Sastre A, Schwemmle M, Boon ACM, Diamond MS, Mehle A. 2020. Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs. Nat Microbiol. doi: 10.1038/s41564-020-0778-x. Online ahead of print.

Lee, S., A. Ishitsuka, M. Noguchi, M. Hirohama, Y. Fujiyasu, P. P. Petric, Schwemmle, P. Staeheli, K. Nagata, and A. Kawaguchi. 2019. Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium. Sci Immunol 4.

Dudek, A. H., F. Pfaff, H. Bolte, C. W. Kontchou, and Schwemmle. 2018. Partial inactivation of the chromatin remodelers SMARCA2 and SMARCA4 in virus-infected cells by caspase-mediated cleavage. J Virol. 92 pii: e00343-18. doi: 10.1128/JVI.00343-18.

Dornfeld, D., A. H. Dudek, T. Vausselin, S. C. Gunther, J. F. Hultquist, S. Giese, D. Khokhlova-Cubberley, Y. C. Chew, N. J. Krogan, A. Garcia-Sastre, Schwemmle, and M. L. Shaw. 2018. SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses. Sci Rep 8: 2092.

Deeg CM, Hassan E, Mutz P, Rheinemann L, Götz V, Magar L, Schilling M, Kallfass C, Nürnberger C, Soubies S, Kochs G, Haller O, Schwemmle M, Staeheli P. 2017. In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein. J Exp Med. 214(5):1239-1248.

Götz V, Magar L, Dornfeld D, Giese S, Pohlmann A, Höper D, Kong BW, Jans DA, Beer M, Haller O, Schwemmle M. 2016. Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import. Sci Rep. 6:23138.  Erratum in: Sci Rep. 2016 May 09