IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spread

Hinz F, Friedel D, Korshunov A, Ippen FM, Bogumil H, Banan R, Brandner S, Hasselblatt M, Boldt HB, Dirse V, Dohmen H, Aronica E, Brodhun M, Broekman MLD, Capper D, Cherkezov A, Deng MY, van Dis V, Felsberg J, Frank S, French PJ, Gerlach R, Göbel K, Goold E, Hench J, Kantelhardt S, Kohlhof-Meinecke P, Krieg S, Mawrin C, Morrison G, Mühlebner A, Ozduman K, Pfister SM, Poliani PL, Prinz M, Reifenberger G, Riemenschneider MJ, Sankowski R, Schrimpf D, Sill M, Snuderl M, Verdijk RM, Voisin MR, Wesseling P, Wick W, Reuss DE, von Deimling A, Sahm F, Maas SLN, Suwala AK. 2025. IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spread. Acta Neuropathol. 149(1):12. doi: 10.1007/s00401-025-02849-8.

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This post was written by Heike Ufheil