Publications

Salié H, Wischer L, D’Alessio A, Godbole I, Suo Y, Otto-Mora P, Beck J, Neumann O, Stenzinger A, Schirmacher P, Fulgenzi CAM, Blaumeiser A, Boerries M, Roehlen N, Schultheiß M, Hofmann M, Thimme R, Pinato DJ, Longerich T, Bengsch B. 2024. Spatial single-cell profiling and neighbourhood analysis reveal the determinants of immune architecture connected to checkpoint inhibitor therapy outcome in hepatocellular carcinoma. Gut. Oct 14:gutjnl-2024-332837. doi: 10.1136/gutjnl-2024-332837.

Geiger RA, Khera D, Tenthorey JL, Kochs G, Graf L, Emerman M, Malik HS. 2024. Heterozygous and generalist MxA super-restrictors overcome breadth-specificity tradeoffs in antiviral restriction. bioRxiv [Preprint]. 2024 Oct 10:2024.10.10.617484. doi: 10.1101/2024.10.10.617484.

Dumas AA, Dalmau Gasull A, Prinz M. 2024. Beyond borders: the choroid plexus-immune communication during neuroinflammation. Signal Transduct Target Ther. 2024 Oct 8;9(1):278. doi: 10.1038/s41392-024-01997-9.

Wenger V, Zeiser R. 2024. Deciphering the role of the major histocompatibility complex, the intestinal microbiome and metabolites in the pathogenesis of acute graft-versus-host disease. Best Pract Res Clin Haematol. 2024 Sep;37(3):101567. doi: 10.1016/j.beha.2024.101567.

Grahammer F, Dumoulin B, Gulieva RE, Wu H, Xu Y, Sulaimanov N, Arnold F, Sandner L, Cordts T, Todkar A, Moulin P, Reichardt W, Puelles VG, Kramann R, Freedman BS, Busch H, Boerries M, Walz G, Huber TB. 2024. Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity. Kidney Int.: S0085-2538(24)00627-6. doi: 10.1016/j.kint.2024.08.021.

Heim K, Sagar, Sogukpinar Ö, Llewellyn-Lacey S, Price DA, Emmerich F, Kraft ARM, Cornberg M, Kielbassa S, Knolle P, Wohlleber D, Bengsch B, Boettler T, Neumann-Haefelin C, Thimme R, Hofmann M. 2024. Attenuated effector T cells are linked to control of chronic HBV infection. Nat Immunol. 25(9):1650-1662. doi: 10.1038/s41590-024-01928-4.

Schamel WW, Zinchenko M, Nguyen T, Fehse B, Briquez PS, Minguet S. 2024. The potential of γδ CAR and TRuC T cells: An unearthed treasure. Eur J Immunol. 2024 Aug 27:e2451074. doi: 10.1002/eji.202451074.

Frosch M, Prinz M. 2024. Novel pathomechanistic insights into lysosomal storage disorders: how neuron-intrinsic cGAS-STING signaling drives disease progression. Signal Transduct Target Ther. 9(1):203. doi: 10.1038/s41392-024-01901-5.

Wogram E, Sümpelmann F, Dong W, Rawat E, Fernández Maestre I, Fu D, Braswell B, Khalil A, Buescher JM, Mittler G, Borner GHH, Vlachos A, Tholen S, Schilling O, Bell GW, Rambold AS, Akhtar A, Schnell O, Beck J, Abu-Remaileh M, Prinz M, Jaenisch R. 2024. Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes. Immunity. S1074-7613(24)00368-6. doi: 10.1016/j.immuni.2024.07.019.

Kuehn JC, Metzger P, Neidert N, Matysiak U, Gräßel L, Philipp U, Bleul S, Pauli T, Falkenstein J, Bertemes H, Cysar S, Hess ME, Frey AV, Duque-Afonso J, Schorb E, Machein M, Beck J, Schnell O, von Bubnoff N, Illert AL, Peters C, Brummer T, Prinz M, Miething C, Becker H, Lassmann S, Werner M, Börries M, Duyster J, Heiland DH, Sankowski R, Scherer F. 2024. Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors. NPJ Precis Oncol. 2024 Aug 14;8(1):180. doi: 10.1038/s41698-024-00674-y.

Wertman RS, Yost W, Herrmann BI, Bourne CM, Sorobetea D, Go CK, Saller BS, Groß O, Scott P, Rongvaux A, Taabazuing CY, Brodsky IE. 2024. Distinct sequential death complexes regulate pyroptosis and IL-1β release in response to Yersinia blockade of immune signaling. Sci Adv. 10(30):eadl3629. doi: 10.1126/sciadv.adl3629.

Bosch M, Kallin N, Donakonda S, Zhang JD, Wintersteller H, Hegenbarth S, Heim K, Ramirez C, Fürst A, Lattouf EI, Feuerherd M, Chattopadhyay S, Kumpesa N, Griesser V, Hoflack JC, Siebourg-Polster J, Mogler C, Swadling L, Pallett LJ, Meiser P, Manske K, de Almeida GP, Kosinska AD, Sandu I, Schneider A, Steinbacher V, Teng Y, Schnabel J, Theis F, Gehring AJ, Boonstra A, Janssen HLA, Vandenbosch M, Cuypers E, Öllinger R, Engleitner T, Rad R, Steiger K, Oxenius A, Lo WL, Klepsch V, Baier G, Holzmann B, Maini MK, Heeren R, Murray PJ, Thimme R, Herrmann C, Protzer U, Böttcher JP, Zehn D, Wohlleber D, Lauer GM, Hofmann M, Luangsay S, Knolle PA.2024. A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection. Nature. 631(8022):867-875. doi: 10.1038/s41586-024-07630-7.

Arnold F, Kupferschmid L, Weissenborn P, Heldmann L, Hummel JF, Zareba P, Sagar, Rogg M, Schell C, Tanriver Y. 2024. Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis. Cell Mol Immunol. Jul 3. doi: 10.1038/s41423-024-01197-z.

Chiang SCC, Covill LE, Tesi B, Campbell TM, Schlums H, Nejati-Zendegani J Mrs, Mördrup K, Wood S, Theorell J, Sekine T, Al Herz W, Akar HH, Belen Apak FB, Chan MY, Devecioglu O, Aksu T, Ifversen M, Malinowska I, Sabel M, Unal E, Unal S, Introne W, Krzewski K, Gilmour KC, Ehl S, Ljunggren HG, Nordenskjöld M, Horne A, Henter JI, Meeths M, Bryceson YT. 2024.  Efficacy of T cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis. Blood. Jul 3:blood.2024024499. doi: 10.1182/blood.2024024499.

Kögl T, Chang HF, Staniek J, Chiang SCC, Thoulass G, Lao J, Weißert K, Dettmer-Monaco V, Geiger K, Manna PT, Beziat V, Momenilandi M, Tu SM, Keppler SJ, Pattu V, Wolf P, Kupferschmid L, Tholen S, Covill LE, Ebert K, Straub T, Groß M, Gather R, Engel H, Salzer U, Schell C, Maier S, Lehmberg K, Cornu TI, Pircher H, Shahrooei M, Parvaneh N, Elling R, Rizzi M, Bryceson YT, Ehl S, Aichele P, Ammann S. 2024. Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect. J Exp Med. 221(7):e20221122. doi: 10.1084/jem.20221122.

Colcerasa A, Friedrich F, Melesina J, Moser P, Vogelmann A, Tzortzoglou P, Neuwirt E, Sum M, Robaa D, Zhang L, Ramos-Morales E, Romier C, Einsle O, Metzger E, Schüle R, Groß O, Sippl W, Jung M. 2024. Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD+-Dependent Lysine Deacylase Sirtuin 2. J Med Chem. 67(12):10076-10095. doi: 10.1021/acs.jmedchem.4c00229.