International Symposium – From Paradigms to Paradoxes in Immunity and Immunopathology (PPII)

Freiburg October 6th-8th 2022 – Save the date!

The conference will highlight and discuss conceptual shifts in basic and translational immunology, infection immunity, immunodeficiency and autoimmunity. It will take place at the University Building KG I located in the heart of Freiburg just a few minutes from the main railway station, hotels and restaurants.

The organizing committee is compiling an exciting scientific program with plenary sessions held by internationally renowned speakers complemented by selected short talks from young scientists.

We cordially invite everyone to join us in Freiburg for this exciting meeting. All Freiburg’ immunologists are looking forward to welcome you to our city with the charm of a small historic town in the heart of the famous Black Forest. We hope to make this special conference a memorable event!


Keynote Speakers:
Steven HOLLAND (Bethesda, USA)
Florian KRAMMER (New York, USA)

Georges Köhler Lecture:
Bruce BEUTLER (La Jolla, USA)

Confirmed Speakers:
Maria CASANOVA-ACEBES (Madrid, Spain)
Andreas DIEFENBACH (Berlin, Germany)
Ali ELLEBEDY (Washington, USA)

Sophie HAMBLETON (Newcastle, UK)
Percy KNOLLE (Munich, Germany)
Burkhard LUDEWIG (St. Gallen, Switzerland)
Diane MATHIS (Boston, USA)
Mihai NETEA (Bonn, Germany & Nijmegen, Netherlands)
Almudena RAMIRO (Madrid, Spain)
Chiara ROMAGNANI (Berlin, Germany)
Charlotte SCOTT (Ghent, Belgium)
Mahima SWAMY (Dundee, UK)
Jürgen WIENANDS (Göttingen, Germany)


October 6th, 2022

12:00 am
Registration & Reception
Session I: Concepts of Basic Molecular Immunology
Chairs: Stephan Ehl, Natalie Köhler
2:00 pm to 2:15 pm
Welcome Note & Opening Ceremonies
2:15 pm to 3:00 pm
KEYNOTE Lecture: Steven Holland
Title: Autoimmunity-induced infections: anticytokine autoantibodies
3:00 pm to 3:30 pm
Burkhard Ludewig
Title: Stromal-immune cell interactions in myocardial inflammation
3:30 pm to 4:00 pm
Jürgen Wienands
Title: B-lymphoid nuclear logistics
4:00 pm to 4:30 pm
Coffee break
Session II: The Paradox of Innate Memory
Chairs: Laura Graf, Philipp Henneke
4:30 pm to 5:00 pm
Chiara Romagnani
Title: Clonality and epigenetic inheritance of NK cell memory
5:00 pm to 5:30 pm
Charlotte Scott
Title: Reexamining the concept of hepatic macrophage plasticity
5:30 pm to 6:00 pm
IMPATH Lecture: Martin Schwemmle
Title: Human MxA: the antiviral gatekeeper of zoonotic influenza viruses
6:15 pm to 7:00 pm
Podium Discussion: Making and breaking disruptive research - obstacles, chances and solutions
Moderation: Marta Rizzi; speakers: Stephan Ehl, Percy Knolle, Almudena Ramiro, Chiara Romagnani, Mahima Swamy

October 7th, 2022

Session III: Paradigms in Infection Immunity
Chairs: Julia Kolter, Robert Thimme
8:00 am to
Registration & Reception
8:30 am to 8:45 am
Michael Reth
Introduction to GEORGES KÖHLER Lecture
8:45 am to 9:45 am
GEORGES KÖHLER Lecture: Bruce Beutler
Title: Germline mutations that suppress cancer growth
9:45 am to 10:15 am
Mihai Netea
Title: Trained immunity: a memory for the innate host defense
10:15 am to 10:30 am
Selected short talk: Kathrin Heim
Diverse mechanisms of HBV-specific CD8+ T-cell dysfunction in chronic infection
10:30 am to 10:45 am
Selected short talk: Daniel Schnepf
Impaired immune response drives age-dependent severity of COVID-19
10:45 am to 11:15 am
Coffee break and industry exhibition
Session IV: Impaired Immune Reactions and Immunopathology
Chairs: Bodo Grimbacher, Maria Elena Maccari
11:15 am to 11:45 am
Sophie Hambleton
Title: When less is more in innate antiviral immunity
11:45 am to 12:00 pm
Selected short talk: Nadine Wössner
Novel approach to modulate T cell activation: from molecular mechanism to control of function
12:00 pm to 12:30 pm
Diane Mathis
Title: Thymic mimetic cells: tolerogenic masqueraders
12:30 pm to 12:45 pm
Selected short talk: Viviane Dettmer-Monaco
Gene Editing of Hematopoietic Stem Cells Restores the Cytotoxic T Cell Response in a Murine Model of Familial Hemophagocytic Lymphohistiocytosis Type 3
12:45 pm to 3:00 pm
Lunch break & industry exhibition
2:00 pm to 2:45 pm
Alexandra Flemming (Chief Editor of Nature Reviews Immunology)
A career jump into science publishing – what’s it like and how do you do it?
Session V: Crosstalk in the Immune System
Chairs: Melanie Börries, Marco Prinz
3:00 pm to 3:30 pm
Percy Knolle
Title: Metabolite-mediated control of T cell immunity in the liver
3:30 pm to 3:45 pm
Selected short talk: Ian Edward Gentle
GM-CSF suppresses LPS induced antioxidant responses through NRF2 downregulation, driving IL-1β ubiquitylation, and secretion
3:45 pm to 4:15 pm
Almudena Ramiro
Antibodies meet the atheroma plaque: a match made in heaven?
4:15 pm to 4:30 pm
Selected short talk: Lukas Amann
Specification of CNS macrophage subsets occurs postnatally in defined niches
4:30 pm to 4:45 pm
Selected short talk: Selina Keppler
B cells fuels intestinal inflammation during autoimmunity
4:45 pm to 5:30 pm
Coffee break & industry exhibition
5:30 pm to 7:00 pm
Science Slam, Wine Tasting & Poster Session
8:00 pm
Social Evening & Prize Ceremony
Wodan Halle, Freiburg

October 8th, 2022

8:30 am to 9:00 am
Registration & Reception
Session VI: Paradoxes in Adverse Immune Responses
Chairs: Bärbel Keller, Christoph Neumann-Haefelin
9:00 am to 9:30 am
Bodo Grimbacher
Basic Science makes a difference: Comparing CTLA4 and NFkB insufficiency
9:30 am to 09:45 am
Selected short talk: Julian Staniek
Non-apoptotic FAS signaling controls CD40-dependent mTOR activation and balances extrafollicular versus germinal center fate in human B cells
09:45 am to 10:00 am
Selected short talk: Carmen Gómez-Escolar
Single cell clonal analysis identifies an AID-dependent pathway of plasma cell differentiation
10:00 am to 10:30 am
Ali Ellebedy
Title: B cell responses to vaccination in humans: Looking beneath the surface
10:30 am to 10:45 am
Selected short talk: Teresa Fuertes
miR-28 enhances the anti-tumoral effect of ibrutinib inducing a cell cycle arrest transcriptional program in aggressive B lymphomas
10:45 am to 11:15 am
Coffee break
Session VII: Frontiers in Mucosal Immunity
Chairs: Laura Gamez-Diaz
11:15 am to 12:00 pm
KEYNOTE Lecture: Florian Krammer
Title: Antibody responses to SARS-CoV-2 after infection and vaccination
12:00 pm to 12:30 pm
Mahima Swamy
Title: Defining the signalling pathways driving tissue-resident T cell responses
12:30 pm to 1:00 pm
Andreas Diefenbach
Title: Innate Lymphoid Cells as checkpoints of tissue homeostasis and adaptation
1:00 pm to 1:10 pm
Closing Remarks
1:10 pm to 2:00 pm
Lunch break

Scientific program committee

  • Maike Hofmann
  • Katrin Kierdorf
  • Susana Minguet
  • Marta Rizzi
  • Heike Ufheil

Symposium Online Registration

COVID-19 update

We are closely monitoring the rapidly changing COVID-19 situation and are committed to creating a safe and effective event experience for all our participants. The health and safety of Meeting delegates are our highest priorities.

On-Site Safety Regulations:

During the Symposium we will apply the so-called ‘2G-Plus rule’ (geimpft, genesen, selbst-getestet – vaccinated, recovered, self-tested). This means that entrance to the Prometheus hall is allowed only to participants belonging to one of these groups. Access is only possible with a mask.

  • Proof of a complete (3-shots) corona vaccination (vaccination pass or digital)
  • Proof of complete recovery from a corona infection (= positive PCR test of a minimum of 28 days and a maximum of 6 months before the visit)

We additionally kindly ask you to perform daily COVID-19 self-testing (antigen test, not older than 24h) as an extra layer of safety. This ensures, in combination with the hygiene regulations and rules, that all visitors and staff stay safe.

Registration and abstract submission closed!


In cooperation with Freiburg Convention Bureau, we reserved a number of hotel rooms in Freiburg for you. Please find all necessary information concerning distances to main station and venue, room rates and cancellation conditions in the booking sheet.

You can book directly online, by booking sheet or by telephone.

For questions about hotel booking please contact:

Freiburg Wirtschaft Touristik und Messe GmbH & Co. KG
Freiburg Convention Bureau
Kerstin Schultheis

Tel.: +49 761 3881 1516


University of Freiburg, KG I
Freiburg im Breisgau


Dr. Heike Ufheil
Breisacher Str. 115
79106 Freiburg i. Brsg.
Phone: +49 (0) 761 / 270-71020