Institute for Medical Bioinformatics and System Medicine
Medical Center – University of Freiburg
Breisacherstr. 153
79110 Freiburg i. Brsg
- +49 (0) 761/ 270 – 84671
- melanie.boerries@uniklinik-freiburg.de
- Homepage

Current position
Director, Institute for Medical Bioinformatics and Systems Medicine, Medical Center – University of Freiburg
Academic training
2001-2005 | Studies of Cell Biology, MD/PhD Program at the University of Basel, Switzerland |
1994 - 2001 | Study of Medicine, University of Lübeck |
Scientific qualifications
2005 | Doctoral degree in Cell Biology (Dr. phil), Biozentrum, University of Basel, Switzerland |
2004 | Doctoral degree in Medicine (Dr. med.), University of Lübeck |
Postgraduate positions
since 2021 | Co-Director of the Tumor Center Freiburg - CCCF |
since 2020 | Head of the Clinical Cancer Registry and IT of the CCCF |
since 2019 | W3 Professor and Director, Institute for Medical Bioinformatics and Systems Medicine (IBSM), Medical Center - University of Freiburg |
Since 2013 | Group leader, German Cancer Consortium (DKTK) |
2009-2012 | Project leader, Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg |
2005-2009 | Postdoctorate, Institute for Experimental and Clinical Pharmakology and Toxicology, University of Freiburg |
2001 - 2005 | Assistant Physician, Department of Cardiology, Inselspital, University of Bern, Switzerland (3 month/year, MD/PhD program) |
Miscellaneous (Honors, Awards)
2006 | Award for innovative teaching projects |
2001 - 2005 | Doctoral scholarship (MD/PhD) of the Maurice E Müller Stiftung, Switzerland |
link to all publications of M. Börries: Pubmed
Publications based on CRC1160 funding
Lenz M, Eichler A, Kruse P, Galanis C, Kleidonas D, Andrieux G, Boerries M, Jedlicka P, Müller U, Deller T, Vlachos A. 2023. The Amyloid Precursor Protein Regulates Synaptic Transmission at Medial Perforant Path Synapses. J Neurosci. 2023 43(29):5290-5304. doi: 10.1523/JNEUROSCI.1824-22.2023.
Raute K, Strietz J, Parigiani MA, Andrieux G, Thomas OS, Kistner KM, Zintchenko M, Aichele P, Hofmann M, Zhou H, Weber W, Boerries M, Swamy M, Maurer J, Minguet S. 2023. Breast Cancer Stem Cell-Derived Tumors Escape from γδ T-cell Immunosurveillance In Vivo by Modulating γδ T-cell Ligands. Cancer Immunol Res. 2023 May 4:OF1-OF20. doi: 10.1158/2326-6066.CIR-22-0296.
Greve G, Andrieux G, Schlosser P, Blagitko-Dorfs N, Rehman UU, Ma T, Pfeifer D, Heil G, Neubauer A, Krauter J, Heuser M, Salih HR, Döhner K, Döhner H, Hackanson B, Boerries M, Lübbert M. 2023. In vivo kinetics of early, non-random methylome and transcriptome changes induced by DNA-hypomethylating treatment in primary AML blasts. Leukemia. 2023 Apr 6. doi: 10.1038/s41375-023-01876-2.
Paul MC, Schneeweis C, Falcomatà C, Shan C, Rossmeisl D, Koutsouli S, Klement C, Zukowska M, Widholz SA, Jesinghaus M, Heuermann KK, Engleitner T, Seidler B, Sleiman K, Steiger K, Tschurtschenthaler M, Walter B, Weidemann SA, Pietsch R, Schnieke A, Schmid RM, Robles MS, Andrieux G, Boerries M, Rad R, Schneider G, Saur D. 2023. Non-canonical functions of SNAIL drive context-specific cancer progression. Nat Commun. Mar 7;14(1):1201. doi: 10.1038/s41467-023-36505-0.
Isbell LK, Tschuch C, Doostkam S, Waldeck S, Andrieux G, Shoumariyeh K, Lenhard D, Schaefer HE, Reinacher PC, Bartsch I, Pantic M, Vinnakota JM, Kakkassery V, Schorb E, Scherer F, Frey AV, Boerries M, Illerhaus G, Duyster J, Schueler J, von Bubnoff N. 2023. Patient-derived xenograft mouse models to investigate tropism to the central nervous system and retina of primary and secondary central nervous system lymphoma. Neuropathol Appl Neurobiol. Mar 6:e12899. doi: 10.1111/nan.12899.
Rhiel M, Geiger K, Andrieux G, Rositzka J, Boerries M, Cathomen T, Cornu TI. 2023. T-CAST: An optimized CAST-Seq pipeline for TALEN confirms superior safety and efficacy of obligate-heterodimeric scaffolds. Front Genome Ed. Feb 20;5:1130736. doi: 10.3389/fgeed.2023.1130736.
Thelen B, Schipperges V, Knörlein P, Hummel JF, Arnold F, Kupferschmid L, Klose CSN, Arnold SJ, Boerries M, Tanriver Y. 2023. Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4+ T cells. Front Immunol. 2023 Jan 19;14:1058267. doi: 10.3389/fimmu.2023.1058267.
van Otterdijk, S. D., H. Klett, M. Boerries, and K. B. Michels. 2023. The impact of pre-pregnancy folic acid intake on placental DNA methylation in a fortified cohort. FASEB J 37: e22698. doi: 10.1096/fj.202200476RR.
Ruckert, T., G. Andrieux, M. Boerries, K. Hanke-Muller, N. M. Woessner, S. Doetsch, C. Schell, K. Aumann, J. Kolter, A. Schmitt-Graeff, M. Schiff, L. M. Braun, E. Haring, S. Kissel, B. A. Siranosian, A. S. Bhatt, P. Nordkild, J. Wehkamp, B. A. H. Jensen, S. Minguet, J. Duyster, R. Zeiser, and N. Kohler. 2022. Human beta-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling. Sci Transl Med 14: eabp9675. doi: 10.1126/scitranslmed.abp9675.
Corrales, E., E. Levit-Zerdoun, P. Metzger, R. Mertes, A. Lehmann, J. Munch, S. Lemke, S. Kowar, and M. Boerries. 2022. PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma. Cell Commun Signal 20: 187. doi: 10.1186/s12964-022-00989-y.
Ferrarese, R., A. Izzo, G. Andrieux, S. Lagies, J. P. Bartmuss, A. P. Masilamani, A. Wasilenko, D. Osti, S. Faletti, R. Schulzki, S. Yuan, E. Kling, V. Ribecco, D. H. Heiland, S. Tholen, Prinz, G. Pelicci, B. Kammerer, M. Boerries, and M. S. Carro. 2023. ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma. Life Sci Alliance 6: e202201400. doi: 10.26508/lsa.202201400.
Bauer, J., N. Kohler, Y. Maringer, P. Bucher, T. Bilich, M. Zwick, S. Dicks, A. Nelde, M. Dubbelaar, J. Scheid, M. Wacker, J. S. Heitmann, S. Schroeder, J. Rieth, M. Denk, M. Richter, R. Klein, I. Bonzheim, J. Luibrand, U. Holzer, M. Ebinger, I. B. Brecht, M. Bitzer, M. Boerries, J. Feucht, H. R. Salih, H. G. Rammensee, S. Hailfinger, and J. S. Walz. 2022. The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma. Nat Commun 13: 6401. doi: 10.1038/s41467-022-33746-3.
Strohmeier, V., G. Andrieux, S. Unger, A. Pascual-Reguant, A. Klocperk, M. Seidl, O. C. Marques, M. Eckert, K. Grawe, M. Shabani, C. von Spee-Mayer, D. Friedmann, I. Harder, S. Gutenberger, B. Keller, M. Proietti, A. Bulashevska, B. Grimbacher, J. Provaznik, V. Benes, S. Goldacker, C. Schell, A. E. Hauser, M. Boerries, P. Hasselblatt, and K. Warnatz. 2022. Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency-Associated Villous Atrophy and Norovirus Infection. J Clin Immunol. pii: 10.1007/s10875-022-01379-2. doi: 10.1007/s10875-022-01379-2.
Chakraborty, S., G. Andrieux, P. Kastl, L. Adlung, S. Altamura, M. E. Boehm, L. E. Schwarzmuller, Y. Abdullah, M. C. Wagner, B. Helm, H. J. Grone, W. D. Lehmann, M. Boerries, H. Busch, M. U. Muckenthaler, M. Schilling, and U. Klingmuller. 2022. Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo. Cell Rep 40: 111360. doi: 10.1016/j.celrep.2022.111360.
Ho, J., D. Schmidt, T. Lowinus, J. Ryoo, E. P. Dopfer, N. Gonzalo Nunez, S. Costa-Pereira, C. Toffalori, M. Punta, V. Fetsch, T. Wertheimer, M. C. Rittmann, L. M. Braun, M. Follo, C. Briere, J. M. Vinnakota, M. Langenbach, F. Koppers, K. Shoumariyeh, H. Engel, T. Ruckert, M. Marklin, S. Holzmayer, A. L. Illert, F. Magon, G. Andrieux, S. Duquesne, D. Pfeifer, J. Staniek, M. Rizzi, C. Miething, N. Kohler, J. Duyster, H. D. Menssen, M. Boerries, J. M. Buescher, N. Cabezas-Wallscheid, B. R. Blazar, P. Apostolova, L. Vago, E. L. Pearce, B. Becher, and R. Zeiser. 2022. Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation. Blood 140: 1167-1181. doi: 10.1182/blood.2022016082.
Braig, D., A. Runkel, A. E. Eisenhardt, A. Schmid, J. Zeller, T. Pauli, U. Lausch, J. Wehrle, P. Bronsert, M. Jung, J. Kiefer, M. Boerries, and S. U. Eisenhardt. 2022. Individualized Mini-Panel Sequencing of ctDNA Allows Tumor Monitoring in Complex Karyotype Sarcomas. Int J Mol Sci 23: pii: ijms231810215. doi: 10.3390/ijms231810215.
Aktories, P., P. Petry, P. Glatz, G. Andrieux, A. Oschwald, H. Botterer, O. Gorka, D. Erny, M. Boerries, P. Henneke, O. Gross, M. Prinz, and K. Kierdorf. 2022. An improved organotypic cell culture system to study tissue-resident macrophages ex vivo. Cell Rep Methods 2: 100260. doi: 10.1016/j.crmeth.2022.100260.
Karlowitz, R., M. L. Stanifer, J. Roedig, G. Andrieux, D. Bojkova, M. Bechtel, S. Smith, L. Kowald, R. Schubert, M. Boerries, J. Cinatl, Jr., S. Boulant, and S. J. L. van Wijk. 2022. USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING. Cell Death Dis 13: 684. doi: 10.1038/s41419-022-05124-w.
Globig AM, Mayer LS, Heeg M, Andrieux G, Ku M, Otto-Mora P, Hipp A, Zoldan K, Pattekar A, Rana N, Schell C, Boerries M, Hofmann M, Neumann-Haefelin C, Kuellmer A, Schmidt A, Boettler T, Tomov V, Thimme R, Hasselblatt P, Bengsch B. Gastroenterology. 2022. Exhaustion of CD39-expressing CD8+ T cells in Crohn’s disease is linked to clinical outcome. First published: 2022 Jun 20:S0016-5085(22)00663-1. doi: 10.1053/j.gastro.2022.06.045. Online ahead of print.
Holzen, L., J. Mitschke, C. Schonichen, M. E. Hess, S. Ehrenfeld, M. Boerries, C. Miething, T. Brummer, and T. Reinheckel. 2022. RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells. Theranostics 12: 4348-4373. doi: 10.7150/thno.68299.
Devane J, Ott E, Olinger EG, Epting D, Decker E, Friedrich A, Bachmann N, Renschler G, Eisenberger T, Briem-Richter A, Grabhorn EF, Powell L, Wilson IJ, Rice SJ, Miles CG, Wood K; Genomics England Research Consortium, Trivedi P, Hirschfield G, Pietrobattista A, Wohler E, Mezina A, Sobreira N, Agolini E, Maggiore G, Dahmer-Heath M, Yilmaz A, Boerries M, Metzger P, Schell C, Grünewald I, Konrad M, König J, Schlevogt B, Sayer JA, Bergmann C. Am J Hum Genet. 2022. Progressive liver, kidney, and heart degeneration in children and adults affected by TULP3 mutations. Published 2022 May 5;109(5):928-943. doi: 10.1016/j.ajhg.2022.03.015. Epub 2022 Apr 8. PMID: 35397207
Haimovici A, Höfer C, Badr MT, Bavafaye Haghighi E, Amer T, Boerries M, Bronsert P, Glavynskyi I, Fanfone D, Ichim G, Thilmany N, Weber A, Brummer T, Spohr C, Öllinger R, Janssen KP, Rad R, Häcker G. 2022. Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse. Cell Death Dis. 2022 13(4):315. doi: 10.1038/s41419-022-04768-y.
Unberath, P., L. Mahlmeister, N. Reimer, H. Busch, M. Boerries, and J. Christoph. 2022. Searching of Clinical Trials Made Easier in cBioPortal Using Patients’ Genetic and Clinical Profiles. Appl Clin Inform 13: 363-369. doi: 10.1055/s-0042-1743560.
Wanner, N., G. Andrieux, I. M. P. Badia, C. Edler, S. Pfefferle, M. T. Lindenmeyer, C. Schmidt-Lauber, J. Czogalla, M. N. Wong, Y. Okabayashi, F. Braun, M. Lutgehetmann, E. Meister, S. Lu, M. L. M. Noriega, T. Gunther, A. Grundhoff, N. Fischer, H. Brauninger, D. Lindner, D. Westermann, F. Haas, K. Roedl, S. Kluge, M. M. Addo, S. Huber, A. W. Lohse, J. Reiser, B. Ondruschka, J. P. Sperhake, J. Saez-Rodriguez, M. Boerries, S. S. Hayek, M. Aepfelbacher, P. Scaturro, V. G. Puelles, and T. B. Huber. 2022. Molecular consequences of SARS-CoV-2 liver tropism. Nat Metab 4: 310-319. doi: 10.1038/s42255-022-00552-6.
Flum, M., S. Dicks, Y. H. Teng, M. Schrempp, A. Nystrom, M. Boerries, and A. Hecht. 2022. Canonical TGFbeta signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT. Oncogene. pii: 10.1038/s41388-022-02190-4. doi: 10.1038/s41388-022-02190-4.
Sharma, R., S. S. Sahoo, M. Honda, S. L. Granger, C. Goodings, L. Sanchez, A. Kunstner, H. Busch, F. Beier, S. M. Pruett-Miller, M. B. Valentine, A. G. Fernandez, T. C. Chang, V. Geli, D. Churikov, S. Hirschi, V. B. Pastor, M. Boerries, M. Lauten, C. Kelaidi, M. A. Cooper, S. Nicholas, J. A. Rosenfeld, S. Polychronopoulou, C. Kannengiesser, C. Saintome, C. M. Niemeyer, P. Revy, M. S. Wold, M. Spies, M. Erlacher, S. Coulon, and M. W. Wlodarski. 2022. Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue. Blood 139: 1039-1051
Aichele P, Neumann-Haefelin C, Ehl S, Thimme R, Cathomen T, Boerries M, Hofmann M. 2022. Immunopathology caused by impaired CD8+ T-cell responses. Eur J Immunol. Jan 31. doi: 10.1002/eji.202149528. Online ahead of print.
Harder, I., M. Munchhalfen, G. Andrieux, Boerries, B. Grimbacher, H. Eibel, M. E. Maccari, S. Ehl, J. Wienands, J. Jellusova, K. Warnatz, and B. Keller. 2022. Dysregulated PI3K Signaling in B Cells of CVID Patients. Cells 11:464. doi: 10.3390/cells11030464.
Kind F, Fassbender TF, Andrieux G, Boerries M, Meyer PT, Ruf J. 2021. Early PSA Change after [177Lu]PSMA-617 Radioligand Therapy as a Predicator of Biochemical Response and Overall Survival. Cancers (Basel). 2021 Dec 29;14(1):149. doi: 10.3390/cancers14010149.
Corrales E, Levit-Zerdoun E, Metzger P, Kowar S, Ku M, Brummer T, Boerries M. 2021. Dynamic transcriptome analysis reveals signatures of paradoxical effect of vemurafenib on human dermal fibroblasts. Cell Commun Signal. 19(1):123. doi: 10.1186/s12964-021-00801-3.
Osswald L, Hamarsheh S, Uhl FM, Andrieux G, Klein C, Dierks C, Duquesne S, Braun LM, Schmitt-Graeff A, Duyster J, Boerries M, Brummer T, Zeiser R. 2021. Oncogenic KrasG12D Activation in the Nonhematopoietic Bone Marrow Microenvironment Causes Myelodysplastic Syndrome in Mice. Mol Cancer Res. 19(9):1596-1608. doi: 10.1158/1541-7786.MCR-20-0275.
Haring E, Andrieux G, Uhl FM, Krausz M, Proietti M, Sauer B, Esser PR, Martin SF, Pfeifer D, Schmitt-Graeff A, Duyster J, Köhler N, Grimbacher B, Boerries M, Aumann K, Zeiser R, Apostolova P. 2021. Therapeutic targeting of endoplasmic reticulum stress in acute graft-versus-host disease. Haematologica. doi: 10.3324/haematol.2021.278387.
Sicklinger F, Meyer IS, Li X, Radtke D, Dicks S, Kornadt MP, Mertens C, Meier JK, Lavine KJ, Zhang Y, Kuhn TC, Terzer T, Patel J, Boerries M, Schramm G, Frey N, Katus HA, Voehringer D, Leuschner F. 2021. Basophils balance healing after myocardial infarction via IL-4/IL-13. J Clin Invest. 131(13):e136778.
Turchiano G, Andrieux G, Klermund J, Blattner G, Pennucci V, El Gaz M, Monaco G, Poddar S, Mussolino C, Cornu TI, Boerries M, Cathomen T. 2021. Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq. Cell Stem Cell. 28(6):1136-1147.e5.
Kläsener K, Jellusova J, Andrieux G, Salzer U, Böhler C, Steiner SN, Albinus JB, Cavallari M, Süß B, Voll RE, Boerries M, Wollscheid B, Reth M. 2021. CD20 as a gatekeeper of the resting state of human B cells. Proc Natl Acad Sci U S A. 118(7):e2021342118.
Maccari, M. E., S. Fuchs, P. Kury, G. Andrieux, S. Volkl, B. Bengsch, M. R. Lorenz, M. Heeg, J. Rohr, S. Jagle, C. N. Castro, M. Gross, U. Warthorst, C. Konig, I. Fuchs, C. Speckmann, J. Thalhammer, F. G. Kapp, M. G. Seidel, G. Duckers, S. Schonberger, C. Schutz, M. Fuhrer, R. Kobbe, D. Holzinger, C. Klemann, P. Smisek, S. Owens, G. Horneff, R. Kolb, N. Naumann-Bartsch, M. Miano, J. Staniek, M. Rizzi, T. Kalina, P. Schneider, A. Erxleben, R. Backofen, A. Ekici, C. M. Niemeyer, K. Warnatz, B. Grimbacher, H. Eibel, A. Mackensen, A. P. Frei, K. Schwarz, M. Boerries, S. Ehl, and A. Rensing-Ehl. 2021. A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS. J Exp Med 218(2):e20192191. doi: 10.1084/jem.20192191.
Bauer C, Quante M, Breunis WB, Regina C, Schneider M, Andrieux G, Gorka O, Groß O, Boerries M, Kammerer B, Hettmer S. 2021. Lack of Electron Acceptors Contributes to Redox Stress and Growth Arrest in Asparagine-Starved Sarcoma Cells. Cancers (Basel). 13(3):412.
Andrieux G, Chakraborty S, Das T, Boerries M. 2020. Alteration of Proteotranscriptomic Landscape Reveals the Transcriptional Regulatory Circuits Controlling Key-Signaling Pathways and Metabolic Reprogramming During Tumor Evolution. Front Cell Dev Biol. 8:586479. doi: 10.3389/fcell.2020.586479.
Uhl, F. M., S. Chen, D. O’Sullivan, J. Edwards-Hicks, G. Richter, E. Haring, G. Andrieux, S. Halbach, P. Apostolova, J. Buscher, S. Duquesne, W. Melchinger, B. Sauer, K. Shoumariyeh, A. Schmitt-Graeff, M. Kreutz, M. Lubbert, J. Duyster, T. Brummer, M. Boerries, T. Madl, B. R. Blazar, O. Gross, E. L. Pearce, and R. Zeiser. 2020. Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans. Sci Transl Med 12:eabb8969. doi: 10.1126/scitranslmed.abb8969.
Haring E, Uhl FM, Andrieux G, Proietti M, Bulashevska A, Sauer B, Braun LM, de Vega Gomez E, Esser PR, Martin SF, Pfeifer D, Follo M, Schmitt-Graeff A, Buescher J, Duyster J, Grimbacher B, Boerries M, Pearce EL, Zeiser R, Apostolova P. Haematologica. 2020. Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect. Jul 16:haematol.2019.242990. doi: 10.3324/haematol.2019.242990. Online ahead of print.
Norona, J., P. Apostolova, D. Schmidt, R. Ihlemann, N. Reischmann, G. Taylor, N. Kohler, J. de Heer, S. Heeg, G. Andrieux, B. A. Siranosian, A. Schmitt-Graeff, D. Pfeifer, A. Catalano, I. Frew, M. Proietti, B. Grimbacher, A. Bulashevska, A. S. Bhatt, T. Brummer, T. S. Clauditz, T. Zabelina, N. Kroeger, B. R. Blazar, M. Boerries, F. Ayuk, and R. Zeiser. 2020. Glucagon like peptide-2 for Intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans. Blood. 2020005957. doi: 10.1182/blood.2020005957. Online ahead of print.
Hamarsheh, S., L. Osswald, B. S. Saller, S. Unger, D. De Feo, J. M. Vinnakota, M. Konantz, F. M. Uhl, H. Becker, M. Lubbert, K. Shoumariyeh, C. Schurch, G. Andrieux, N. Venhoff, A. Schmitt-Graeff, S. Duquesne, D. Pfeifer, M. A. Cooper, C. Lengerke, M. Boerries, J. Duyster, C. M. Niemeyer, M. Erlacher, B. R. Blazar, B. Becher, O. Gross, T. Brummer, and R. Zeiser. 2020. Oncogenic Kras(G12D) causes myeloproliferation via NLRP3 inflammasome activation. Nat Commun 11: 1659.
Marschner, D., M. Falk, N. R. Javorniczky, K. Hanke-Muller, J. Rawluk, Schmitt-Graeff, F. Simonetta, E. Haring, S. Dicks, M. Ku, S. Duquesne, K. Aumann, D. Rafei-Shamsabadi, F. Meiss, P. Marschner, M. Boerries, R. S. Negrin, J. Duyster, R. Zeiser, and N. Kohler. 2020. MicroRNA-146a regulates immune-related adverse events caused by immune checkpoint inhibitors. JCI insight 5. pii: 132334. doi: 10.1172/jci.insight.132334.
R Mathew N, Vinnakota JM, Apostolova P, Erny D, Hamarsheh S, Andrieux G, Kim JS, Hanke K, Goldmann T, Chappell-Maor L, El-Khawanky N, Ihorst G, Schmidt D, Duyster J, Finke J, Blank T, Boerries M, Blazar BR, Jung S, Prinz M, Zeiser R. 2019. Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia. J Clin Invest. pii: 130272.