Melanie Börries

Prof. Dr. Dr.
Principal Investigator

Institute for Medical Bioinformatics and System Medicine​
Medical Center – University of Freiburg

Breisacherstr. 153
79110 Freiburg i. Brsg

Current position

Director, Institute for Medical Bioinformatics and Systems Medicine, Medical Center – University of Freiburg

Academic training

2001-2005 Studies of Cell Biology, MD/PhD Program at the University of Basel, Switzerland
1994 - 2001 Study of Medicine, University of Lübeck

Scientific qualifications

2005 Doctoral degree in Cell Biology (Dr. phil), Biozentrum, University of Basel, Switzerland
2004 Doctoral degree in Medicine (Dr. med.), University of Lübeck

Postgraduate positions

since 2021 Co-Director of the Tumor Center Freiburg - CCCF
since 2020 Head of the Clinical Cancer Registry and IT of the CCCF
since 2019 W3 Professor and Director, Institute for Medical Bioinformatics and Systems Medicine (IBSM), Medical Center - University of Freiburg
Since 2013 Group leader, German Cancer Consortium (DKTK)
2009-2012 Project leader, Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg
2005-2009 Postdoctorate, Institute for Experimental and Clinical Pharmakology and Toxicology, University of Freiburg
2001 - 2005 Assistant Physician, Department of Cardiology, Inselspital, University of Bern, Switzerland (3 month/year, MD/PhD program)

Miscellaneous (Honors, Awards)

2006 Award for innovative teaching projects
2001 - 2005 Doctoral scholarship (MD/PhD) of the Maurice E Müller Stiftung, Switzerland

link to all publications of M. Börries: Pubmed

Publications based on CRC1160 funding

Klermund J, Rhiel M, Kocher T, Chmielewski KO, Bischof J, Andrieux G, El Gaz M, Hainzl S, Boerries M, Cornu TI, Koller U, Cathomen T. 2024. On- and off-target effects of paired CRISPR-Cas nickase in primary human cells. Mol Ther. S1525-0016(24)00147-3. doi: 10.1016/j.ymthe.2024.03.006.

Czech M, Schneider S, Peltokangas N, El Khawanky N, Ghimire S, Andrieux G, Hülsdünker J, Krausz M, Proietti M, Braun LM, Rückert T, Langenbach M, Schmidt D, Martin I, Wenger V, de Vega E, Haring E, Pourjam M, Pfeifer D, Schmitt-Graeff A, Grimbacher B, Aumann K, Kircher B, Tilg H, Raffatellu M, Thiele Orberg E, Häcker G, Duyster J, Köhler N, Holler E, Nachbaur D, Boerries M, Gerner RR, Grün D, Zeiser R. 2024. Lipocalin-2 expression identifies an intestinal regulatory neutrophil population during acute graft-versus-host disease. Sci Transl Med. 2024 Feb 21;16(735):eadi1501. doi: 10.1126/scitranslmed.adi1501.

Ramamoorthy S, Lebrecht D, Schanze D, Schanze I, Wieland I, Andrieux G, Metzger P, Hess M, Albert MH, Borkhardt A, Bresters D, Buechner J, Catala A, De Haas V, Dworzak M, Erlacher M, Hasle H, Jahnukainen K, Locatelli F, Masetti R, Stary J, Turkiewicz D, Vinci L, Wlodarski MW, Yoshimi A, Boerries M, Niemeyer CM, Zenker M, Flotho C. 2024.  Biallelic inactivation of the NF1 tumour suppressor gene in juvenile myelomonocytic leukaemia: Genetic evidence of driver function and implications for diagnostic workup. Br J Haematol. 2024 Feb;204(2):595-605. doi: 10.1111/bjh.19190.

Weinelt N, Wächtershäuser KN, Celik G, Jeiler B, Gollin I, Zein L, Smith S, Andrieux G, Das T, Roedig J, Feist L, Rotter B, Boerries M, Pampaloni F, van Wijk SJL. 2024. LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL. Cell Death Dis. 20;15(1):77. doi: 10.1038/s41419-024-06447-6.

Staniek J, Kalina T, Andrieux G, Boerries M, Janowska I, Fuentes M, Díez P, Bakardjieva M, Stancikova J, Raabe J, Neumann J, Schwenk S, Arpesella L, Stuchly J, Benes V, García Valiente R, Fernández García J, Carsetti R, Piano Mortari E, Catala A, de la Calle O, Sogkas G, Neven B, Rieux-Laucat F, Magerus A, Neth O, Olbrich P, Voll RE, Alsina L, Allende LM, Gonzalez-Granado LI, Böhler C, Thiel J, Venhoff N, Lorenzetti R, Warnatz K, Unger S, Seidl M, Mielenz D, Schneider P, Ehl S, Rensing-Ehl A, Smulski CR, Rizzi M. 2024. Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells. Sci Immunol. Jan 12;9(91):eadj5948. doi: 10.1126/sciimmunol.adj5948.

Maas-Bauer K, Stell AV, Yan KL, de Vega E, Vinnakota JM, Unger S, Núñez N, Norona J, Talvard-Balland N, Koßmann S, Schwan C, Miething C, Martens US, Shoumariyeh K, Nestor RP, Duquesne S, Hanke K, Rackiewicz M, Hu Z, El Khawanky N, Taromi S, Andrlova H, Faraidun H, Walter S, Pfeifer D, Follo M, Waldschmidt J, Melchinger W, Rassner M, Wehr C, Schmitt-Graeff A, Halbach S, Liao J, Häcker G, Brummer T, Dengjel J, Andrieux G, Grosse R, Tugues S, Blazar BR, Becher B, Boerries M, Zeiser R. 2024. ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease. Nat Commun. 15(1):446. doi: 10.1038/s41467-024-44703-7.

Torella L, Klermund J, Bilbao-Arribas M, Tamayo I, Andrieux G, Chmielewski KO, Vales A, Olagüe C, Moreno-Luqui D, Raimondi I, Abad A, Torrens-Baile J, Salido E, Huarte M, Hernaez M, Boerries M, Cathomen T, Zabaleta N, Gonzalez-Aseguinolaza G. 2024. Efficient and safe therapeutic use of paired Cas9-nickases for primary hyperoxaluria type 1. EMBO Mol Med. 2024 Jan 5. doi: 10.1038/s44321-023-00008-8.

Dettmer-Monaco V, Weißert K, Ammann S, Monaco G, Lei L, Gräßel L, Rhiel M, Rositzka J, Kaufmann MM, Geiger K, Andrieux G, Lao J, Thoulass G, Schell C, Boerries M, Illert AL, Cornu TI, Ehl S, Aichele P, Cathomen T. 2024. Gene editing of hematopoietic stem cells restores T-cell response in familial hemophagocytic lymphohistiocytosis. J Allergy Clin Immunol. Jan;153(1):243-255.e14. doi: 10.1016/j.jaci.2023.08.003.

Wu, Y., P. M. A. Zehnle, J. Rajak, N. Koleci, G. Andrieux, L. Gallego-Villar, K. Aumann, M. Boerries, C. M. Niemeyer, C. Flotho, S. Bohler, and M. Erlacher. 2023. BH3 mimetics and azacitidine show synergistic effects on juvenile myelomonocytic leukemia. Leukemia. doi:10.1038/s41375-023-02079-5.

Ramamoorthy, S., D. Lebrecht, D. Schanze, I. Schanze, I. Wieland, G. Andrieux, P. Metzger, M. Hess, M. H. Albert, A. Borkhardt, D. Bresters, J. Buechner, A. Catala, V. De Haas, M. Dworzak, M. Erlacher, H. Hasle, K. Jahnukainen, F. Locatelli, R. Masetti, J. Stary, D. Turkiewicz, L. Vinci, M. W. Wlodarski, A. Yoshimi, M. Boerries, C. M. Niemeyer, M. Zenker, and C. Flotho. 2023. Biallelic inactivation of the NF1 tumour suppressor gene in juvenile myelomonocytic leukaemia: Genetic evidence of driver function and implications for diagnostic workup. Br J Haematol. doi:10.1111/bjh.19190.

Velasco Cárdenas RM, Brandl SM, Meléndez AV, Schlaak AE, Buschky A, Peters T, Beier F, Serrels B, Taromi S, Raute K, Hauri S, Gstaiger M, Lassmann S, Huppa JB, Boerries M, Andrieux G, Bengsch B, Schamel WW, Minguet S. 2023. Harnessing CD3 diversity to optimize CAR T cells. Nat Immunol. 24(12):2135-2149. doi: 10.1038/s41590-023-01658-z.

Nelde A, Schuster H, Heitmann JS, Bauer J, Maringer Y, Zwick M, Volkmer JP, Chen JY, Stanger AMP, Lehmann A, Appiah B, Märklin M, Rücker-Braun E, Salih HR, Roerden M, Schroeder SM, Häring MF, Schlosser A, Schetelig J, Schmitz M, Boerries M, Köhler N, Lengerke C, Majeti R, Weissman IL, Rammensee HG, Walz JS. 2023. Immune Surveillance of Acute Myeloid Leukemia Is Mediated by HLA-Presented Antigens on Leukemia Progenitor Cells. Blood Cancer Discov. 4(6):468-489. doi: 10.1158/2643-3230.BCD-23-0020.

Apostolova P, Kreutmair S, Toffalori C, Punta M, Unger S, Burk AC, Wehr C, Maas-Bauer K, Melchinger W, Haring E, Hoefflin R, Shoumariyeh K, Hupfer V, Lauer EM, Duquesne S, Lowinus T, Gonzalo Núñez N, Alberti C, da Costa Pereira S, Merten CH, Power L, Weiss M, Böke C, Pfeifer D, Marks R, Bertz H, Wäsch R, Ihorst G, Gentner B, Duyster J, Boerries M, Andrieux G, Finke J, Becher B, Vago L, Zeiser R. 2023. Phase II trial of hypomethylating agent combined with nivolumab for acute myeloid leukaemia relapse after allogeneic haematopoietic cell transplantation-Immune signature correlates with response. Br J Haematol. 2023 Oct;203(2):264-281. doi: 10.1111/bjh.19007.

Lenz M, Eichler A, Kruse P, Galanis C, Kleidonas D, Andrieux G, Boerries M, Jedlicka P, Müller U, Deller T, Vlachos A. 2023. The Amyloid Precursor Protein Regulates Synaptic Transmission at Medial Perforant Path Synapses. J Neurosci. 2023 43(29):5290-5304. doi: 10.1523/JNEUROSCI.1824-22.2023.

Andrieux G, Das T, Griffin M, Straehle J, Paine SML, Beck J, Boerries M, Heiland DH, Smith SJ, Rahman R, Chakraborty S. 2023. Spatially resolved transcriptomic profiles reveal unique defining molecular features of infiltrative 5ALA-metabolizing cells associated with glioblastoma recurrence. Genome Med. 2023 Jul 11;15(1):48. doi: 10.1186/s13073-023-01207-1.

Raute K, Strietz J, Parigiani MA, Andrieux G, Thomas OS, Kistner KM, Zintchenko M, Aichele P, Hofmann M, Zhou H, Weber W, Boerries M, Swamy M, Maurer J, Minguet S. 2023. Breast Cancer Stem Cell-Derived Tumors Escape from γδ T-cell Immunosurveillance In Vivo by Modulating γδ T-cell Ligands. Cancer Immunol Res. 2023 May 4:OF1-OF20. doi: 10.1158/2326-6066.CIR-22-0296.

Greve G, Andrieux G, Schlosser P, Blagitko-Dorfs N, Rehman UU, Ma T, Pfeifer D, Heil G, Neubauer A, Krauter J, Heuser M, Salih HR, Döhner K, Döhner H, Hackanson B, Boerries M, Lübbert M. 2023. In vivo kinetics of early, non-random methylome and transcriptome changes induced by DNA-hypomethylating treatment in primary AML blasts. Leukemia. 2023 Apr 6. doi: 10.1038/s41375-023-01876-2.

Paul MC, Schneeweis C, Falcomatà C, Shan C, Rossmeisl D, Koutsouli S, Klement C, Zukowska M, Widholz SA, Jesinghaus M, Heuermann KK, Engleitner T, Seidler B, Sleiman K, Steiger K, Tschurtschenthaler M, Walter B, Weidemann SA, Pietsch R, Schnieke A, Schmid RM, Robles MS, Andrieux G, Boerries M, Rad R, Schneider G, Saur D. 2023. Non-canonical functions of SNAIL drive context-specific cancer progression. Nat Commun. Mar 7;14(1):1201. doi: 10.1038/s41467-023-36505-0.

Isbell LK, Tschuch C, Doostkam S, Waldeck S, Andrieux G, Shoumariyeh K, Lenhard D, Schaefer HE, Reinacher PC, Bartsch I, Pantic M, Vinnakota JM, Kakkassery V, Schorb E, Scherer F, Frey AV, Boerries M, Illerhaus G, Duyster J, Schueler J, von Bubnoff N. 2023. Patient-derived xenograft mouse models to investigate tropism to the central nervous system and retina of primary and secondary central nervous system lymphoma. Neuropathol Appl Neurobiol. Mar 6:e12899. doi: 10.1111/nan.12899.

Rhiel M, Geiger K, Andrieux G, Rositzka J, Boerries M, Cathomen T, Cornu TI. 2023. T-CAST: An optimized CAST-Seq pipeline for TALEN confirms superior safety and efficacy of obligate-heterodimeric scaffolds. Front Genome Ed. Feb 20;5:1130736. doi: 10.3389/fgeed.2023.1130736.

Strohmeier V, Andrieux G, Unger S, Pascual-Reguant A, Klocperk A, Seidl M, Marques OC, Eckert M, Gräwe K, Shabani M, von Spee-Mayer C, Friedmann D, Harder I, Gutenberger S, Keller B, Proietti M, Bulashevska A, Grimbacher B, Provaznik J, Benes V, Goldacker S, Schell C, Hauser AE, Boerries M, Hasselblatt P, Warnatz K. 2023. Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency-Associated Villous Atrophy and Norovirus Infection. J Clin Immunol. 43(2):371-390. doi: 10.1007/s10875-022-01379-2.

Thelen B, Schipperges V, Knörlein P, Hummel JF, Arnold F, Kupferschmid L, Klose CSN, Arnold SJ, Boerries M, Tanriver Y. 2023. Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4+ T cells. Front Immunol. 2023 Jan 19;14:1058267. doi: 10.3389/fimmu.2023.1058267.

Antón-García P, Haghighi EB, Rose K, Vladimirov G, Boerries M, Hecht A. 2023. TGFβ1-Induced EMT in the MCF10A Mammary Epithelial Cell Line Model Is Executed Independently of SNAIL1 and ZEB1 but Relies on JUNB-Coordinated Transcriptional Regulation. Cancers (Basel). 2023 Jan 16;15(2):558. doi: 10.3390/cancers15020558.

van Otterdijk, S. D., H. Klett, M. Boerries, and K. B. Michels. 2023. The impact of pre-pregnancy folic acid intake on placental DNA methylation in a fortified cohort. FASEB J 37: e22698. doi: 10.1096/fj.202200476RR.

Ruckert, T., G. Andrieux, M. Boerries, K. Hanke-Muller, N. M. Woessner, S. Doetsch, C. Schell, K. Aumann, J. Kolter, A. Schmitt-Graeff, M. Schiff, L. M. Braun, E. Haring, S. Kissel, B. A. Siranosian, A. S. Bhatt, P. Nordkild, J. Wehkamp, B. A. H. Jensen, S. Minguet, J. Duyster, R. Zeiser, and N. Kohler. 2022. Human beta-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling. Sci Transl Med 14: eabp9675. doi: 10.1126/scitranslmed.abp9675.

Corrales, E., E. Levit-Zerdoun, P. Metzger, R. Mertes, A. Lehmann, J. Munch, S. Lemke, S. Kowar, and M. Boerries. 2022. PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma. Cell Commun Signal 20: 187. doi: 10.1186/s12964-022-00989-y.

Ferrarese, R., A. Izzo, G. Andrieux, S. Lagies, J. P. Bartmuss, A. P. Masilamani, A. Wasilenko, D. Osti, S. Faletti, R. Schulzki, S. Yuan, E. Kling, V. Ribecco, D. H. Heiland, S. Tholen, Prinz, G. Pelicci, B. Kammerer, M. Boerries, and M. S. Carro. 2023. ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma. Life Sci Alliance 6: e202201400. doi: 10.26508/lsa.202201400.

Bauer, J., N. Kohler, Y. Maringer, P. Bucher, T. Bilich, M. Zwick, S. Dicks, A. Nelde, M. Dubbelaar, J. Scheid, M. Wacker, J. S. Heitmann, S. Schroeder, J. Rieth, M. Denk, M. Richter, R. Klein, I. Bonzheim, J. Luibrand, U. Holzer, M. Ebinger, I. B. Brecht, M. Bitzer, M. Boerries, J. Feucht, H. R. Salih, H. G. Rammensee, S. Hailfinger, and J. S. Walz. 2022. The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma. Nat Commun 13: 6401. doi: 10.1038/s41467-022-33746-3.

Strohmeier, V., G. Andrieux, S. Unger, A. Pascual-Reguant, A. Klocperk, M. Seidl, O. C. Marques, M. Eckert, K. Grawe, M. Shabani, C. von Spee-Mayer, D. Friedmann, I. Harder, S. Gutenberger, B. Keller, M. Proietti, A. Bulashevska, B. Grimbacher, J. Provaznik, V. Benes, S. Goldacker, C. Schell, A. E. Hauser, M. Boerries, P. Hasselblatt, and K. Warnatz. 2022. Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency-Associated Villous Atrophy and Norovirus Infection. J Clin Immunol. pii: 10.1007/s10875-022-01379-2. doi: 10.1007/s10875-022-01379-2.

Chakraborty, S., G. Andrieux, P. Kastl, L. Adlung, S. Altamura, M. E. Boehm, L. E. Schwarzmuller, Y. Abdullah, M. C. Wagner, B. Helm, H. J. Grone, W. D. Lehmann, M. Boerries, H. Busch, M. U. Muckenthaler, M. Schilling, and U. Klingmuller. 2022. Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo. Cell Rep 40: 111360. doi: 10.1016/j.celrep.2022.111360.

Ho, J., D. Schmidt, T. Lowinus, J. Ryoo, E. P. Dopfer, N. Gonzalo Nunez, S. Costa-Pereira, C. Toffalori, M. Punta, V. Fetsch, T. Wertheimer, M. C. Rittmann, L. M. Braun, M. Follo, C. Briere, J. M. Vinnakota, M. Langenbach, F. Koppers, K. Shoumariyeh, H. Engel, T. Ruckert, M. Marklin, S. Holzmayer, A. L. Illert, F. Magon, G. Andrieux, S. Duquesne, D. Pfeifer, J. Staniek, M. Rizzi, C. Miething, N. Kohler, J. Duyster, H. D. Menssen, M. Boerries, J. M. Buescher, N. Cabezas-Wallscheid, B. R. Blazar, P. Apostolova, L. Vago, E. L. Pearce, B. Becher, and R. Zeiser. 2022. Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation. Blood 140: 1167-1181. doi: 10.1182/blood.2022016082.

Braig, D., A. Runkel, A. E. Eisenhardt, A. Schmid, J. Zeller, T. Pauli, U. Lausch, J. Wehrle, P. Bronsert, M. Jung, J. Kiefer, M. Boerries, and S. U. Eisenhardt. 2022. Individualized Mini-Panel Sequencing of ctDNA Allows Tumor Monitoring in Complex Karyotype Sarcomas. Int J Mol Sci 23: pii: ijms231810215. doi: 10.3390/ijms231810215.

Aktories, P., P. Petry, P. Glatz, G. Andrieux, A. Oschwald, H. Botterer, O. Gorka, D. Erny, M. Boerries, P. Henneke, O. Gross, M. Prinz, and K. Kierdorf. 2022. An improved organotypic cell culture system to study tissue-resident macrophages ex vivo. Cell Rep Methods 2: 100260. doi: 10.1016/j.crmeth.2022.100260.

Karlowitz, R., M. L. Stanifer, J. Roedig, G. Andrieux, D. Bojkova, M. Bechtel, S. Smith, L. Kowald, R. Schubert, M. Boerries, J. Cinatl, Jr., S. Boulant, and S. J. L. van Wijk. 2022. USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING. Cell Death Dis 13: 684. doi: 10.1038/s41419-022-05124-w.

Globig AM, Mayer LS, Heeg M, Andrieux G, Ku M, Otto-Mora P, Hipp A, Zoldan K, Pattekar A, Rana N, Schell C, Boerries M, Hofmann M, Neumann-Haefelin C, Kuellmer A, Schmidt A, Boettler T, Tomov V, Thimme R, Hasselblatt P, Bengsch B. Gastroenterology. 2022. Exhaustion of CD39-expressing CD8+ T cells in Crohn’s disease is linked to clinical outcome. First published: 2022 Jun 20:S0016-5085(22)00663-1. doi: 10.1053/j.gastro.2022.06.045. Online ahead of print.

Holzen, L., J. Mitschke, C. Schonichen, M. E. Hess, S. Ehrenfeld, M. Boerries, C. Miething, T. Brummer, and T. Reinheckel. 2022. RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells. Theranostics 12: 4348-4373. doi: 10.7150/thno.68299.

Hölzen L, Mitschke J, Schönichen C, Hess ME, Ehrenfeld S, Boerries M, Miething C, Brummer T, Reinheckel T. 2022. RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells. Theranostics. 12(9):4348-4373. doi: 10.7150/thno.68299.

Devane J, Ott E, Olinger EG, Epting D, Decker E, Friedrich A, Bachmann N, Renschler G, Eisenberger T, Briem-Richter A, Grabhorn EF, Powell L, Wilson IJ, Rice SJ, Miles CG, Wood K; Genomics England Research Consortium, Trivedi P, Hirschfield G, Pietrobattista A, Wohler E, Mezina A, Sobreira N, Agolini E, Maggiore G, Dahmer-Heath M, Yilmaz A, Boerries M, Metzger P, Schell C, Grünewald I, Konrad M, König J, Schlevogt B, Sayer JA, Bergmann C. Am J Hum Genet. 2022.  Progressive liver, kidney, and heart degeneration in children and adults affected by TULP3 mutations. Published 2022 May 5;109(5):928-943. doi: 10.1016/j.ajhg.2022.03.015. Epub 2022 Apr 8. PMID: 35397207

Haimovici A, Höfer C, Badr MT, Bavafaye Haghighi E, Amer T, Boerries M, Bronsert P, Glavynskyi I, Fanfone D, Ichim G, Thilmany N, Weber A, Brummer T, Spohr C, Öllinger R, Janssen KP, Rad R, Häcker G. 2022. Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse. Cell Death Dis. 2022 13(4):315. doi: 10.1038/s41419-022-04768-y.

Unberath, P., L. Mahlmeister, N. Reimer, H. Busch, M. Boerries, and J. Christoph. 2022. Searching of Clinical Trials Made Easier in cBioPortal Using Patients’ Genetic and Clinical Profiles. Appl Clin Inform 13: 363-369. doi: 10.1055/s-0042-1743560.

Wanner, N., G. Andrieux, I. M. P. Badia, C. Edler, S. Pfefferle, M. T. Lindenmeyer, C. Schmidt-Lauber, J. Czogalla, M. N. Wong, Y. Okabayashi, F. Braun, M. Lutgehetmann, E. Meister, S. Lu, M. L. M. Noriega, T. Gunther, A. Grundhoff, N. Fischer, H. Brauninger, D. Lindner, D. Westermann, F. Haas, K. Roedl, S. Kluge, M. M. Addo, S. Huber, A. W. Lohse, J. Reiser, B. Ondruschka, J. P. Sperhake, J. Saez-Rodriguez, M. Boerries, S. S. Hayek, M. Aepfelbacher, P. Scaturro, V. G. Puelles, and T. B. Huber. 2022. Molecular consequences of SARS-CoV-2 liver tropism. Nat Metab 4: 310-319. doi: 10.1038/s42255-022-00552-6.

Flum, M., S. Dicks, Y. H. Teng, M. Schrempp, A. Nystrom, M. Boerries, and A. Hecht. 2022. Canonical TGFbeta signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT. Oncogene. pii: 10.1038/s41388-022-02190-4. doi: 10.1038/s41388-022-02190-4.

Sharma, R., S. S. Sahoo, M. Honda, S. L. Granger, C. Goodings, L. Sanchez, A. Kunstner, H. Busch, F. Beier, S. M. Pruett-Miller, M. B. Valentine, A. G. Fernandez, T. C. Chang, V. Geli, D. Churikov, S. Hirschi, V. B. Pastor, M. Boerries, M. Lauten, C. Kelaidi, M. A. Cooper, S. Nicholas, J. A. Rosenfeld, S. Polychronopoulou, C. Kannengiesser, C. Saintome, C. M. Niemeyer, P. Revy, M. S. Wold, M. Spies, M. Erlacher, S. Coulon, and M. W. Wlodarski. 2022. Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue. Blood 139: 1039-1051

Aichele P, Neumann-Haefelin C, Ehl S, Thimme R, Cathomen T, Boerries M, Hofmann M. 2022. Immunopathology caused by impaired CD8+ T-cell responses. Eur J Immunol. Jan 31. doi: 10.1002/eji.202149528. Online ahead of print.

Harder, I., M. Munchhalfen, G. Andrieux, Boerries, B. Grimbacher, H. Eibel, M. E. Maccari, S. Ehl, J. Wienands, J. Jellusova, K. Warnatz, and B. Keller. 2022. Dysregulated PI3K Signaling in B Cells of CVID Patients. Cells 11:464. doi: 10.3390/cells11030464.

Kind F, Fassbender TF, Andrieux G, Boerries M, Meyer PT, Ruf J. 2021. Early PSA Change after [177Lu]PSMA-617 Radioligand Therapy as a Predicator of Biochemical Response and Overall Survival. Cancers (Basel). 2021 Dec 29;14(1):149. doi: 10.3390/cancers14010149.

Corrales E, Levit-Zerdoun E, Metzger P, Kowar S, Ku M, Brummer T, Boerries M. 2021. Dynamic transcriptome analysis reveals signatures of paradoxical effect of vemurafenib on human dermal fibroblasts. Cell Commun Signal. 19(1):123. doi: 10.1186/s12964-021-00801-3.

Osswald L, Hamarsheh S, Uhl FM, Andrieux G, Klein C, Dierks C, Duquesne S, Braun LM, Schmitt-Graeff A, Duyster J, Boerries M, Brummer T, Zeiser R. 2021. Oncogenic KrasG12D Activation in the Nonhematopoietic Bone Marrow Microenvironment Causes Myelodysplastic Syndrome in Mice. Mol Cancer Res. 19(9):1596-1608. doi: 10.1158/1541-7786.MCR-20-0275.

Haring E, Andrieux G, Uhl FM, Krausz M, Proietti M, Sauer B, Esser PR, Martin SF, Pfeifer D, Schmitt-Graeff A, Duyster J, Köhler N, Grimbacher B, Boerries M, Aumann K, Zeiser R, Apostolova P. 2021. Therapeutic targeting of endoplasmic reticulum stress in acute graft-versus-host disease. Haematologica. doi: 10.3324/haematol.2021.278387.

Sicklinger F, Meyer IS, Li X, Radtke D, Dicks S, Kornadt MP, Mertens C, Meier JK, Lavine KJ, Zhang Y, Kuhn TC, Terzer T, Patel J, Boerries M, Schramm G, Frey N, Katus HA, Voehringer D, Leuschner F. 2021. Basophils balance healing after myocardial infarction via IL-4/IL-13. J Clin Invest. 131(13):e136778.

Turchiano G, Andrieux G, Klermund J, Blattner G, Pennucci V, El Gaz M, Monaco G, Poddar S, Mussolino C, Cornu TI, Boerries M, Cathomen T. 2021. Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq. Cell Stem Cell. 28(6):1136-1147.e5.

Kläsener K, Jellusova J, Andrieux G, Salzer U, Böhler C, Steiner SN, Albinus JB, Cavallari M, Süß B, Voll RE, Boerries M, Wollscheid B, Reth M. 2021. CD20 as a gatekeeper of the resting state of human B cells. Proc Natl Acad Sci U S A. 118(7):e2021342118.

Maccari, M. E., S. Fuchs, P. Kury, G. Andrieux, S. Volkl, B. Bengsch, M. R. Lorenz, M. Heeg, J. Rohr, S. Jagle, C. N. Castro, M. Gross, U. Warthorst, C. Konig, I. Fuchs, C. Speckmann, J. Thalhammer, F. G. Kapp, M. G. Seidel, G. Duckers, S. Schonberger, C. Schutz, M. Fuhrer, R. Kobbe, D. Holzinger, C. Klemann, P. Smisek, S. Owens, G. Horneff, R. Kolb, N. Naumann-Bartsch, M. Miano, J. Staniek, M. Rizzi, T. Kalina, P. Schneider, A. Erxleben, R. Backofen, A. Ekici, C. M. Niemeyer, K. Warnatz, B. Grimbacher, H. Eibel, A. Mackensen, A. P. Frei, K. Schwarz, M. Boerries, S. Ehl, and A. Rensing-Ehl. 2021. A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS. J Exp Med 218(2):e20192191. doi: 10.1084/jem.20192191.

Bauer C, Quante M, Breunis WB, Regina C, Schneider M, Andrieux G, Gorka O, Groß O, Boerries M, Kammerer B, Hettmer S. 2021. Lack of Electron Acceptors Contributes to Redox Stress and Growth Arrest in Asparagine-Starved Sarcoma Cells. Cancers (Basel). 13(3):412.

Andrieux G, Chakraborty S, Das T, Boerries M. 2020. Alteration of Proteotranscriptomic Landscape Reveals the Transcriptional Regulatory Circuits Controlling Key-Signaling Pathways and Metabolic Reprogramming During Tumor Evolution.  Front Cell Dev Biol. 8:586479. doi: 10.3389/fcell.2020.586479.

Uhl, F. M., S. Chen, D. O’Sullivan, J. Edwards-Hicks, G. Richter, E. Haring, G. Andrieux, S. Halbach, P. Apostolova, J. Buscher, S. Duquesne, W. Melchinger, B. Sauer, K. Shoumariyeh, A. Schmitt-Graeff, M. Kreutz, M. Lubbert, J. Duyster, T. Brummer, M. Boerries, T. Madl, B. R. Blazar, O. Gross, E. L. Pearce, and R. Zeiser. 2020. Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans. Sci Transl Med 12:eabb8969. doi: 10.1126/scitranslmed.abb8969.

Haring E, Uhl FM, Andrieux G, Proietti M, Bulashevska A, Sauer B, Braun LM, de Vega Gomez E, Esser PR, Martin SF, Pfeifer D, Follo M, Schmitt-Graeff A, Buescher J, Duyster J, Grimbacher B, Boerries M, Pearce EL, Zeiser R, Apostolova P. Haematologica. 2020. Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect. Jul 16:haematol.2019.242990. doi: 10.3324/haematol.2019.242990. Online ahead of print.

Norona, J., P. Apostolova, D. Schmidt, R. Ihlemann, N. Reischmann, G. Taylor, N. Kohler, J. de Heer, S. Heeg, G. Andrieux, B. A. Siranosian, A. Schmitt-Graeff, D. Pfeifer, A. Catalano, I. Frew, M. Proietti, B. Grimbacher, A. Bulashevska, A. S. Bhatt, T. Brummer, T. S. Clauditz, T. Zabelina, N. Kroeger, B. R. Blazar, M. Boerries, F. Ayuk, and R. Zeiser. 2020. Glucagon like peptide-2 for Intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans. Blood. 2020005957. doi: 10.1182/blood.2020005957. Online ahead of print.

Hamarsheh, S., L. Osswald, B. S. Saller, S. Unger, D. De Feo, J. M. Vinnakota, M. Konantz, F. M. Uhl, H. Becker, M. Lubbert, K. Shoumariyeh, C. Schurch, G. Andrieux, N. Venhoff, A. Schmitt-Graeff, S. Duquesne, D. Pfeifer, M. A. Cooper, C. Lengerke, M. Boerries, J. Duyster, C. M. Niemeyer, M. Erlacher, B. R. Blazar, B. Becher, O. Gross, T. Brummer, and R. Zeiser. 2020. Oncogenic Kras(G12D) causes myeloproliferation via NLRP3 inflammasome activation. Nat Commun 11: 1659.

Marschner, D., M. Falk, N. R. Javorniczky, K. Hanke-Muller, J. Rawluk, Schmitt-Graeff, F. Simonetta, E. Haring, S. Dicks, M. Ku, S. Duquesne, K. Aumann, D. Rafei-Shamsabadi, F. Meiss, P. Marschner, M. Boerries, R. S. Negrin, J. Duyster, R. Zeiser, and N. Kohler. 2020. MicroRNA-146a regulates immune-related adverse events caused by immune checkpoint inhibitors. JCI insight 5. pii: 132334. doi: 10.1172/jci.insight.132334.

R Mathew N, Vinnakota JM, Apostolova P, Erny D, Hamarsheh S, Andrieux G, Kim JS, Hanke K, Goldmann T, Chappell-Maor L, El-Khawanky N, Ihorst G, Schmidt D, Duyster J, Finke J, Blank T, Boerries M, Blazar BR, Jung S, Prinz M, Zeiser R. 2019. Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia. J Clin Invest. pii: 130272.