Yakup Tanriver

Dr.
Principal Investigator

Center for Medicine
Department of Medicine IV &
Department for Microbiology, Virology and Hygiene
Medical Center – University of Freiburg

Hermann Herder Str. 11
79104 Freiburg i. Brsg.

Current position

Attending physician and Group leader, Department of Medicine IV, Center for Medicine, Medical Center – University of Freiburg

Academic training

1994 – 2001 Study of Medicine in Berlin

Scientific qualifications

2020 Habilitation in Internal Medicine
2002 Dissertation in Medicine, Charité, Berlin
(Supervisor: Prof. R. Schindler)

Postgraduate Positions

since 2016 Attending physician, Department of Medicine IV,
Medical Center - University of Freiburg
since 2010 Group leader, Department of Medicine IV,
Medical Center - University of Freiburg
2016 Board Examen Nephrology and Internal Medicine
2009 - 2016 Assistant physician, Department of Medicine IV,
Medical Center - University of Freiburg
2005 – 2008 Postdoctorate, King’s College, Immunoregulation Lab, London, UK
2002 – 2005 Assistant physician in Internal Medicine, Department of Nephrology and Intensive Care, Berlin

Miscellaneous (Honors, Awards)

2010 – 2012 Walter-Hitzig Fellow, Center for Chronic Immunodeficiency, Freiburg

link to all publications from Y. Tanriver: Pubmed

Publications based on CRC1160 funding

Herr LA, Fiala GJ, Sagar, Schaffer AM, Hummel JF, Zintchenko M, Raute K, Velasco Cárdenas RM, Heizmann B, Ebert K, Fehrenbach K, Janowska I, Chan S, Tanriver Y, Minguet S, Schamel WW. 2024. Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals. Sci Adv. 10(11):eadj2802. doi: 10.1126/sciadv.adj2802.

Matuschik L, Seifert G, Lammich K, Holzner P, Tanriver Y, Fichtner-Feigl S, Walz G, Schneider J, Jänigen B. 2024. Non-antigen-specific Immunoadsorption Is a Risk Factor for Severe Postoperative Infections in ABO-Incompatible Kidney Transplant Recipients. Transpl Int. 37:12263. doi: 10.3389/ti.2024.12263.

Thelen B, Schipperges V, Knörlein P, Hummel JF, Arnold F, Kupferschmid L, Klose CSN, Arnold SJ, Boerries M, Tanriver Y. 2023. Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4+ T cells. Front Immunol. 2023 Jan 19;14:1058267. doi: 10.3389/fimmu.2023.1058267.

Tanriver, U., F. Emmerich, J. F. Hummel, B. Janigen, M. Panning, F. Arnold, and Y. Tanriver. 2022. IFNL4 rs368234815 polymorphism does not predict risk of BK virus associated nephropathy after living-donor kidney transplant: A case-control study. Clin Transplant 36: e14663. doi: 10.1111/ctr.14663.

Kemming, J., S. Gundlach, M. Panning, D. Huzly, J. Huang, M. Lutgehetmann, S. Pischke, J. Schulze Zur Wiesch, F. Emmerich, S. Llewellyn-Lacey, D. A. Price, Y. Tanriver, K. Warnatz, T. Boettler, R. Thimme, M. Hofmann, N. Fischer, and C. Neumann-Haefelin. 2022. Mechanisms of CD8+ T-cell failure in chronic hepatitis E virus infection. J Hepatol 77: 978-990. doi: 10.1016/j.jhep.2022.05.019.

Zeiser R, Warnatz K, Rosshart S, Sagar, Tanriver Y. 2022. GVHD, IBD and primary immunodeficiencies: The gut as a target of immunopathology resulting from impaired immunity. Eur J Immunol. 52(9):1406-1418. doi: 10.1002/eji.202149530.

Guendel, F., M. Kofoed-Branzk, K. Gronke, C. Tizian, M. Witkowski, H. W. Cheng, G. A. Heinz, F. Heinrich, P. Durek, P. S. Norris, C. F. Ware, C. Ruedl, S. Herold, K. Pfeffer, T. Hehlgans, A. Waisman, B. Becher, A. D. Giannou, S. Brachs, K. Ebert, Y. Tanriver, B. Ludewig, M. F. Mashreghi, A. A. Kruglov, and A. Diefenbach. 2020. Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues. Immunity 53: 1015-1032 e1018.

Arnold F, Westermann L, Rieg S, Neumann-Haefelin E, Biever PM, Walz G, Kalbhenn J, Tanriver Y. 2020. Comparison of different anticoagulation strategies for renal replacement therapy in critically ill patients with COVID-19: a cohort study.  BMC Nephrol. 21(1):486. doi: 10.1186/s12882-020-02150-8.

Fixemer J, Hummel JF, Arnold F, Klose CSN, Hofherr A, Weissert K, Kögl T, Köttgen M, Arnold SJ, Aichele P, Tanriver Y. 2020. Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells. PLoS Pathog. 16(9):e1008870. doi: 10.1371/journal.ppat.1008870.

Rafei-Shamsabadi DA, Klose CSN, Halim TYF, Tanriver Y, Jakob T. 2019. Context Dependent Role of Type 2 Innate Lymphoid Cells in Allergic Skin Inflammation. Front Immunol. 2019 10:2591. doi: 10.3389/fimmu.2019.02591. eCollection 2019.

Hummel JF, Zeis P, Ebert K, Fixemer J, Konrad P, Schachtrup C, Arnold SJ, Grün D, Tanriver Y. 2019. Single-cell RNA-sequencing identifies the developmental trajectory of C-Myc-dependent NK1.1- T-bet+ intraepithelial lymphocyte precursors. Mucosal Immunol. doi: 10.1038/s41385-019-0220-y. [Epub ahead of print]

Mathew NR, Baumgartner F, Braun L, O’Sullivan D, Thomas S, Waterhouse M, Müller TA, Hanke K, Taromi S, Apostolova P, Illert AL, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lübbert M, Rummelt C, Bertz H, Wäsch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rösler W, Doostkam S, Meckel S,Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stölzel F, Ordemann R, Müller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kröger N, Ayuk F, Vago L, Ciceri F, Müller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dörfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Börries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K, Shah O, Negrin RS, Nagler A, Prinz M, Burchert A, Neubauer A, Beelen D, Mackensen A, von Bubnoff N, Herr W, Becher B, Socié G, Caligiuri MA, Ruggiero E, Bonini C, Häcker G, Duyster J, Finke J, Pearce E, Blazar BR, Zeiser R. Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nat Med. 24: 282-291.

Friedmann, D., B. Keller, I. Harder, J. Schupp, Tanriver, S. Unger, and K. Warnatz. 2017. Preferential Reduction of Circulating Innate Lymphoid Cells Type 2 in Patients with Common Variable Immunodeficiency with Secondary Complications Is Part of a Broader Immune Dysregulation. J Clin Immunol 37: 759-769.

Klose CSN, Hummel JF, Faller L, d’Hargues Y, Ebert K, Tanriver Y. 2018. A committed postselection precursor to natural TCRαβ(+) intraepithelial lymphocytes. Mucosal Immunol. 11(2):333-344.

Probst S, Daza RA, Bader N, Hummel JF, Weiß M, Tanriver Y, Hevner RF, Arnold SJ. 2017. A dual-fluorescence reporter in the Eomes locus for live imaging and medium-term lineage tracing. Genesis. 55(8). doi: 10.1002/dvg.23043.