The role of T-bet in the function of CD8αα + intraepithelial lymphocytes (IELs) to ameliorate intestinal immunopathology

Project Summary

This project will dissect the non-redundant roles of the T-box transcription factor T-bet in maintaining intestinal immune homeostasis through its actions in CD8aa+ intraepithelial lymphocytes. This will be achieved by employing two newly generated and unpublished mouse lines, which lack expression of T-bet but, unexpectedly, show normal numbers and distribution of CD8aa+ intraepithelial lymphocytes. Analysis will combine functional in vivo experiment with mechanistic studies on the single cell and molecular level.