Projects

Project Area A: Impaired T cell functions resulting in immunopathology

A01

Stephan Ehl
Peter Aichele

Genetic defects impairing lymphocyte cytotoxicity: causes and consequences

A02

Maike Hofmann
Robert Thimme

Diverging mechanisms of virus-specific CD8 T cell dysfunction result in protective versus pathogenic responses in chronic hepatitis B virus infection

A03

Bertram Bengsch

Pathogenic instruction of CD8 T cell differentiation in Crohn's disease

A06

Christoph Neumann-Haefelin

Mechanisms of hepatitis E virus persistence and immunopathology in immunocompromised patients

A08N

Maria Elena Maccari
Anne Rensing-Ehl

Lymphoproliferative disease resulting from impaired deletion of FAS controlled T cells

Project Area B: Signals and cells regulating immunopathology

B01

Susana Minguet

Caveolin-1 and Filamin A: a novel mechanistic axis regulating B cell responses and immunopathology

B02

Marta Rizzi

Autoimmunity because of defective B cell fate decisions in autoimmune lymphoproliferative syndrome

B03

Dimitra Kiritsi
Alexander Nyström

Immune-mediated pathology as a consequence of impaired lymphocyte-extracellular matrix interactions

B05

Bodo Grimbacher

Studying the intestinal microbiome as a driver for immune pathology in CTLA4 insufficient individuals and mice

B08

Sagar
Yakup Tanriver

Bi-directional communication between intraepithelial lymphocytes and epithelial cells to maintain intestinal barrier integrity

B09

Natalie Köhler
Robert Zeiser

Overcoming intestinal immune dysregulation by metabolic modification during acute graft-versus-host-disease

B10N

Stephan Rosshart
Robert Zeiser

Impact of wild-type intestinal microbiome on impaired immune regulation during acute graft-versus-host disease

Project Area C: Impaired macrophage homeostasis resulting in immunopathology

C01

Laura Graf
Martin Schwemmle

Immunopathology resulting from lack of early control of influenza virus infection by interferon-induced Mx proteins: causes and consequences

C02

Olaf Groß

GM-CSF-induced impairment of macrophage homeostasis resulting in lung immunopathology

C03

Marco Prinz

Mapping cellular interactions of human tissue macrophages during health and immune-mediated pathologies by spatial proteogenomics

C05N

Katrin Kierdorf

CTSD-deficiency in macrophages links impaired lysosomal function to immune-mediated pathology across different organs

C06N

Philipp Henneke

Macrophage dysregulation as cause of chronic inflammation in NADPH oxidase deficiency

Central Projects

Z01

Christoph Schell
Bertram Bengsch

Immunopathology Unit

Z02

Melanie Börries
Sagar

Bioinformatics Core

INF(N)

Harald Binder

Information infrastructure for research data management

Scientific Manager/Administration
Dr. Heike Ufheil
Institute for Immunodeficiency,
Center for Chronic Immunodeficiency (CCI)
Medical Center – University of Freiburg

+49 (0) 761 / 270-71020 info@sfb1160.uni-freiburg.de

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