Projects

Project Area A: The impaired immune reaction and its reconstitution

A01

Stephan Ehl

Human genetic defects impairing lymphocyte cytotoxicity: causes and consequences

A02

Maike Hofmann
Robert Thimme

Mechanisms of antigen-dependent CD8 T cell dysfunction in chronic HBV infection

A03N

Bertram Bengsch

Role of T cell exhaustion in autoimmune-mediated disease

A04

Klaus Warnatz

Tipping the balance: Immune-mediated pathologies in CVID enteropathy

A06

Christoph Neumann-Haefelin

Mechanisms of hepatitis E virus persistence and immunopathology in immunocompromised patients

A07

Peter Aichele
Toni Cathomen
Stephan Ehl

A preclinical therapeutic gene editing protocol to restore cytotoxic T cell function in acute haemophagocytic lymphohistiocytosis

Project Area B: Signals and cells regulating immunopathology

B01

Susana Minguet

Impaired B cell responses in the absence of Caveolin-1 lead to immunopathology: towards mechanistic insights

B02

Marta Rizzi

Disruption of non-apoptotic Fas signalling disturbs B cell activation in autoimmune lymphoproliferative syndrome

B03N

Dimitra Kiritsi
Alexander Nyström

Immune-mediated pathology as a consequence of impaired lymphocyte-extracellular matrix interactions

B04

Peter Aichele

Role of the CD4 T cell compartment in modulating HLH progression

B05N

Bodo Grimbacher

Identification of disease modifiers in the pathophysiology of CTLA-4 insufficiency

B07N

Thomas Boehm

Molecular basis for the generation of a self-tolerant TCR repertoire

B08

Yakup Tanriver

The role of T-bet in the function of CD8αα + intraepithelial lymphocytes (IELs) to ameliorate intestinal immunopathology

B09

Robert Zeiser

Promoting tolerogenic neutrophils during GVHD

Project Area C: Innate control of immune-mediated pathology

C01

Martin Schwemmle

Immunopathology resulting from lack of early control of influenza virus infection by interferon-induced Mx proteins: causes and consequences

C02N

Olaf Groß

Regulation of NLRP3 inflammasome licensing in autoinflammation

C03

Marco Prinz

The macrophage-specific function of Hexb in tissue homeostasis

C04N

Edward Pearce

Metabolic regulation of macrophage activation in haemophagocytic lymphohistiocytosis (HLH)

Central Projects

Z01

Christoph Schell

Immunopathology Unit

Z02N

Melanie Börries

Bioinformatics Core

Scientific Manager/Administration
Dr. Heike Ufheil
Institute for Immunodeficiency,
Center for Chronic Immunodeficiency (CCI)
Medical Center – University of Freiburg

+49 (0) 761 / 270-71020 info@sfb1160.uni-freiburg.de

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