Immune-mediated pathology as a consequenceof impaired immune reactions
Immune-mediated pathology as a consequence
of impaired immune reactions
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Project Area A:
The impaired immune reaction and its reconstitution
A01
Stephan Ehl
Human genetic defects impairing lymphocyte cytotoxicity: causes and consequences
A02
Maike Hofmann
Robert Thimme
Mechanisms of antigen-dependent CD8 T cell dysfunction in chronic HBV infection
A03N
Bertram Bengsch
Role of T cell exhaustion in autoimmune-mediated disease
A04
Klaus Warnatz
Tipping the balance: Immune-mediated pathologies in CVID enteropathy
A06
Christoph Neumann-Haefelin
Mechanisms of hepatitis E virus persistence and immunopathology in immunocompromised patients
A07
Peter Aichele
Toni Cathomen
Stephan Ehl
A preclinical therapeutic gene editing protocol to restore cytotoxic T cell function in acute haemophagocytic lymphohistiocytosis
Project Area B:
Signals and cells regulating immunopathology
B01
Susana Minguet
Impaired B cell responses in the absence of Caveolin-1 lead to immunopathology: towards mechanistic insights
B02
Marta Rizzi
Disruption of non-apoptotic Fas signalling disturbs B cell activation in autoimmune lymphoproliferative syndrome
B03N
Dimitra Kiritsi
Alexander Nyström
Immune-mediated pathology as a consequence of impaired lymphocyte-extracellular matrix interactions
B04
Peter Aichele
Role of the CD4 T cell compartment in modulating HLH progression
B05N
Bodo Grimbacher
Identification of disease modifiers in the pathophysiology of CTLA-4 insufficiency
B07N
Thomas Boehm
Molecular basis for the generation of a self-tolerant TCR repertoire
B08
Yakup Tanriver
The role of T-bet in the function of CD8αα + intraepithelial lymphocytes (IELs) to ameliorate intestinal immunopathology
B09
Robert Zeiser
Promoting tolerogenic neutrophils during GVHD
Project Area C:
Innate control of immune-mediated pathology
C01
Martin Schwemmle
Immunopathology resulting from lack of early control of influenza virus infection by interferon-induced Mx proteins: causes and consequences
C02N
Olaf Groß
Regulation of NLRP3 inflammasome licensing in autoinflammation
C03
Marco Prinz
The macrophage-specific function of Hexb in tissue homeostasis
C04N
Edward Pearce
Metabolic regulation of macrophage activation in haemophagocytic lymphohistiocytosis (HLH)
Central Projects
Z01
Christoph Schell
Immunopathology Unit
Z02N
Melanie Börries
Bioinformatics Core