Immune-mediated pathology as a consequenceof impaired immune reactions
Immune-mediated pathology as a consequence
of impaired immune reactions
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Projects
Project Area A:
Impaired T cell functions resulting in immunopathology
A01
Stephan Ehl
Peter Aichele
Genetic defects impairing lymphocyte cytotoxicity: causes and consequences
A02
Maike Hofmann
Robert Thimme
Diverging mechanisms of virus-specific CD8 T cell dysfunction result in protective versus pathogenic responses in chronic hepatitis B virus infection
A03
Bertram Bengsch
Pathogenic instruction of CD8 T cell differentiation in Crohn's disease
A06
Christoph Neumann-Haefelin
Mechanisms of hepatitis E virus persistence and immunopathology in immunocompromised patients
A08N
Maria Elena Maccari
Anne Rensing-Ehl
Lymphoproliferative disease resulting from impaired deletion of FAS controlled T cells
Project Area B:
Signals and cells regulating immunopathology
B01
Susana Minguet
Caveolin-1 and Filamin A: a novel mechanistic axis regulating B cell responses and immunopathology
B02
Marta Rizzi
Autoimmunity because of defective B cell fate decisions in autoimmune lymphoproliferative syndrome
B03
Dimitra Kiritsi
Alexander Nyström
Immune-mediated pathology as a consequence of impaired lymphocyte-extracellular matrix interactions
B05
Bodo Grimbacher
Studying the intestinal microbiome as a driver for immune pathology in CTLA4 insufficient individuals and mice
B08
Sagar
Yakup Tanriver
Bi-directional communication between intraepithelial lymphocytes and epithelial cells to maintain intestinal barrier integrity
B09
Natalie Köhler
Robert Zeiser
Overcoming intestinal immune dysregulation by metabolic modification during acute graft-versus-host-disease
B10N
Stephan Rosshart
Robert Zeiser
Impact of wild-type intestinal microbiome on impaired immune regulation during acute graft-versus-host disease
Project Area C:
Impaired macrophage homeostasis resulting in immunopathology
C01
Laura Graf
Martin Schwemmle
Immunopathology resulting from lack of early control of influenza virus infection by interferon-induced Mx proteins: causes and consequences
C02
Olaf Groß
GM-CSF-induced impairment of macrophage homeostasis resulting in lung immunopathology
C03
Marco Prinz
Mapping cellular interactions of human tissue macrophages during health and immune-mediated pathologies by spatial proteogenomics
C05N
Katrin Kierdorf
CTSD-deficiency in macrophages links impaired lysosomal function to immune-mediated pathology across different organs
C06N
Philipp Henneke
Macrophage dysregulation as cause of chronic inflammation in NADPH oxidase deficiency
Central Projects
Z01
Christoph Schell
Bertram Bengsch
Immunopathology Unit
Z02
Melanie Börries
Sagar
Bioinformatics Core
INF(N)
Harald Binder
Information infrastructure for research data management