Project Summary
Patients with Autoimmune lymphoproliferative syndrome (ALPS) suffer from autoantibody mediated autoimmunity and lymphoproliferation and carry mutations in the Fas gene. The Fas mutation leads to a defective germinal centre selection of B cells explaining the susceptibility to autoimmunity in these patients. In the second funding period, the impact of Fas mutations on non-apoptotic Fas signalling will be studied with a focus on B cell activation.
