Mapping cellular interactions of human tissue macrophages during health and immune-mediated pathologies by spatial proteogenomics

Project Summary

C03, Prinz, will continue to investigate tissue macrophage features and cellular interactions during Sandhoff disease, a lysosomal storage disease, characterized by systemic immunopathology resulting from impaired macrophage homeostasis. Based on these disease-specific insights and the associated technological advances, C03 will tackle the highly ambitious project to establish a comprehensive organ atlas of cellular crosstalk between distinct stromal cells and tissue macrophages in relation to their spatial neighborhood. Anatomical niches surrounding tissue macrophage subsets will be carefully explored.