Overcoming intestinal immune dysregulation by metabolic modification during acute graft-versus-host-disease

Project Summary

In B09, Köhler/Zeiser will follow the hypothesis that one of the factors leading to the immunopathology of graft-versus-host disease (GvHD) is a dysregulated intestinal metabolite milieu. They aim to study how the decline of certain metabolites, including linoleic acid and oleic acid, contributes to the impaired immunosuppressive function of immunoregulatory cells during aGvHD. For this, they will use cell culture approaches, murine aGvHD models, genetic mouse models and aGvHD patient samples.