Tipping the balance: Immune-mediated pathologies in CVID enteropathy

Project Summary

Immune-mediated gastrointestinal disease is a severe complication in patients with common variable immunodeficiency (CVID). Our current findings suggest a dysbalance of T-cell mediated immunity causing the enteropathy in the context of the disturbed local IgA production​ due to the underlying humoral immunodeficiency. By the cross-sectional and longitudinal analysis of the local and systemic alterations of T-cell homeostasis, activation of local innate cells, interferon network and the epithelial integrity in comparison to autoimmune enteropathy and gastrointestinal graft-versus-host disease, the project aims to improve diagnostics and to define targets for treatment of this severe manifestation in patients with CVID.